Product Description
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.
Biovision | A1868 | Anti-STRADA Antibody DataSheet
Antibody Target: STRADA
Target Alternative Name: Stlk, PMSE, STE20-related kinase adaptor alpha, STRADA, STRAD, LYK5, NY-BR-96
Tag Line: Affinity purified Rabbit polyclonal to STRADA
Category: Primary antibody
Host: Rabbit
Isotype: Rabbit IgG
Species Reactivities: Mouse
Immunogen Sequence: Recombinant fusion protein containing a sequence corresponding to amino acids 25-210 of human STRADA (NP_699166.2).
Accession #: Q7RTN6
Gene ID: 92335
Appearance: Liquid
Form: Liquid
Concentration:
Formulation: Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification: Affinity Purification
Application: Western Blotting
Positive Control:
Application And Usages: WB 1:1000 - 1:2000
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: True
Immunocytochemistry Verified: False
Immunofluorescence Verified: False
Immunoprecipitation Verified: False
FACS Verified: False
ELISA Verified: False
ChIP Verified: False
Dot Blot Verified: False
Flow Cytometry Verified: False