Product Description
Biovision | SAR-407899 free base | B3356
Description: SAR-407899 is a potent and selective Rho kinase (ROCK) inhibitor with potential antihypertensive activity. SAR-407899 is equipotent against human and rat-derived Rho-kinase 2 with IC50 values of 36 nM and 41 nM, respectively. SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries. The antihypertensive effect of SAR-407899 is superior to that of Fasudil (Cat. No. 1787) and Y-27632 (Cat. No. 1596).
Alternate Name/Synonyms: 6-(piperidin-4-yloxy)isoquinolin-1(2H)-one SAR407899
Appearance: Solid
Formulation:
CAS Number: 923359-38-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₄H₁₆N₂O₂
Molecular Weight: 244.29
Cell-Permeable?: TRUE
Purity: ≥98%
Solubilities: >5 mg/ml DMSO
Handling: Do not taWear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Tag Line: A potent and selective ROCK inhibitor
MDL Number:
PubChem CID:
PubChem CID Link:
SMILES: O=C1NC=CC2=C1C=CC(OC3CCNCC3)=C2
InChi: InChI=1S/C14H16N2O2/c17-14-13-2-1-12(9-10(13)3-8-16-14)18-11-4-6-15-7-5-11/h1-3,8-9,11,15H,4-7H2,(H,16,17)
InChi Key: IPEXHQGMTHOKQV-UHFFFAOYSA-N
Category: Biochemicals