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Biovision | Lersivirine | B3305

Lersivirine is a non-nucleoside, next generation reverse transcriptase inhibitor (IC50 = 118 nM for the wild-type HIV-1 enzyme). It inhibits a panel of 14 single-point mutant HIV-1 reverse...

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Biovision | Vorapaxar | B3304

Vorapaxar (SCH-530348) is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar inhibits thrombin receptor-activating...

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Biovision | Rimegepant | B3303

Rimegepant is an oral antagonist of the calcitonin gene-related peptide (CGRP) receptor (Ki = 0.027 nM). It inhibits cAMP production stimulated by α-CGRP in SK-N-MC human neuroblastoma cells (IC50 =...

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Biovision | XTT Sodium Salt | B3302

XTT sodium is a useful dye to measure cell proliferation, cytotoxicity, and apoptosis through colorimetric assay. XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a...

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Biovision | Euphol | B3301

Euphol is a naturally occurring tetracyclic triterpene that displays anti-inflammatory action. Euphol produces anti-inflammatory effects by mediating NF-κB, down-regulation of tumor necrosis factor-α...

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Biovision | CSF1R-IN-1 | B3300

CSF1R-IN-1, is a potent CSF1R inhibitor (IC50 of 0.5 nM). CSF1R plays an important role in the recruitment and differentiation of tumor-associated macrophages (TAM).CSF1R-IN-1, is a potent CSF1R...

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Biovision | Flucytosine | B3299

Flucytosine, a fluorinated pyrimidine analog that displays antifungal activities. 5-FC is deaminated by cytosine deaminase to product 5-fluorouracil, resulting in RNA miscoding. Flucytosine inhibits...

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Biovision | MYF-01-37 | B3298

MYF-01-37 is a novel covalent inhibitor of TEAD (transcriptional enhanced associate domain) targeting Cys380 when incubated with the TEAD2 protein.MYF-01-37 is a novel covalent inhibitor of TEAD...

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Biovision | Cinacalcet hydrochloride | B3297

Cinacalcet is a calcimimetic and an allosteric agonist of the calcium-sensing receptor. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to...

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Biovision | Resazurin sodium | B3296

Resazurin is a blue fluorogenic dye used as a redox indicator in cell viability and proliferation assays for bacteria, yeast or mammalian cells. The blue form of the dye is irreversibly reduced by...

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Biovision | Bepridil hydrochloride | B3295

Bepidril hydrochloride is a non-selective calcium channel blocker and class IV antiarrhythmic agent. Also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels; acts...

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Biovision | BAEE | B3294

BAEE (N-α-Benzoyl-L-arginine ethyl ester) is a nonpeptide substrate of proteases and deiminases. It has been used as a substrate for the determination of trypsin activity. Additionally, BAEE has also...

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Biovision | BRD-5529 | B3293

BRD-5529 is a selective, cell-permeable CARD9-E3 ubiquitin ligase TRIM62 protein-protein interaction inhibitor (IC50 of 8.6 μM). BRD-5529 directly and selectively binds CARD9, disrupts TRIM62...

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Biovision | GLPG-0974 | B3292

GLPG-0974 is a potent FFA2 (free fatty acid receptor 2) antagonist (IC50 = 9 nM). Displays selectivity for FFA2 over FFA3. GLPG-0974 inhibits acetate-induced migration of isolated human neutrophils...

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Biovision | (2R,6R)-Hydroxynorketamine | B3291

(2R,6R)-Hydroxynorketamine hydrochloride is a ketamine metabolite that enhances AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Decreases...

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Biovision | (±)-Eriodictyol | B3290

(±)-Eriodictyol is a natural flavonoid with potential antioxidation activity. Eriodictyol Inhibits proliferation, metastasis and induces apoptosis of glioma cells via PI3K/Akt/NF-κB Signaling Pathway...

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Biovision | Pinocembrin | B3289

Pinocembrin is a natural product isolated from the leaves of A. zerumbet. It displays enhanced alkaline phosphatase (ALP) activity and mineralization and increased mRNA expression of...

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Biovision | AZ-191 | B3288

AZ-191 is a potent and selective DYRK1B (dual-specificity tyrosine phosphorylation-regulated kinase 1B) inhibitor (IC50 = 17 nM). AZ-191 selectively inhibits DYRK1B in vitro and in cells. DYRK1B is...

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Biovision | DIRK1A/1B inhibitor AnnH31 | B3287

DIRK1A/1B inhibitor AnnH31 is a potent selective cell-permeable DYRK1A (IC50 =81 nM) and DYRK1B inhibitor. Off-target inhibition of CLK1 and slightly DYRK2 and HIPK2. Displays minimal inhibitory...

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Biovision | Acetohydroxamic acid | B3286

Acetohydroxamic acid is a potent inhibitor of bacterial urease activity and reduces urinary ammonia levels. It inhibits the growth of struvite crystals produced by P. mirabilis in artificial urine...

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Biovision | LDN-192960 hydrochloride | B3285

LDN-192960 dihydrochloride is an inhibitor of Haspin protein kinase and dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) with IC50 values of 10 and 48 nM, respectively. It...

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Biovision | Quetiapine hemifumarate | B3284

Quetiapine fumarate Displays antagonist activity at serotonin (5-HT2) and dopamine (D2) receptors (IC50 values are 148 and 329 nM respectively). Lacks affinity at either D1 or muscarinic receptors...

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Biovision | SB-265610 | B3283

SB-265610 is a potent and selective CXCR2 chemokine receptor antagonist (Kd = 2.5 nM). It does not bind to CXCR1). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in...

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Biovision | SB-225002 | B3282

SB-225002 is a potent and selective inhibitor of chemokine receptor CXCR2 with an IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2; displays > 150-fold selectivity over CXCR1 receptors...

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Biovision | Eugenol | B3281

Eugenol, the major constituent of clove oil that possesses significant antioxidant, anti-inflammatory and cardiovascular properties, in addition to analgesic and local anesthetic activity. Eugenol...

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Biovision | Topiramate | B3280

Topiramate is a potent antiepileptic drug with a broad spectrum of activity. Topiramate acts as an antagonist of GluK1 kainate receptors (IC50 = 0.46 μM); also acts as a positive allosteric modulator...

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Biovision | Zonisamide | B3279

Zonisamide is a broad-spectrum sulfonamide derivative with an anticonvulsant property. Zonisamide appears to block sodium and calcium channels, thereby stabilizing neuronal membranes and suppressing...

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Biovision | 4-CPPC | B3278

4-CPPC is a potent, reversible and selective small molecule inhibitor of the pro-inflammatory protein macrophage migration inhibitory factor-2 (a.k.a. MIF-2 or D-DT) (IC50 = 27 µM). 4-CPPC...

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Biovision | A-443654 | B3277

A-443654 is a pan-Akt inhibitor and has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM). Also acts as a DYRK1A inhibitor (IC50=10nM). Inhibits other kinases, including PRK2, MSK1...

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Biovision | Glycoursodeoxycholic acid | B3276

Glycoursodeoxycholic acid (GUDCA) is a glycine-conjugated form of the secondary bile acid ursodeoxycholic acid. It displays antioxidant effects in vitro in Barrett’s esophagus cells and primary...

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Biovision | Sodium tauroursodeoxycholate | B3275

Tauroursodeoxycholic acid (TUDCA) is a taurine-conjugated form of the secondary bile acid ursodeoxycholic acid. TUDCA is found in small quantities in human bile but at a higher concentration in the...

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Biovision | Sodium taurodeoxycholate | B3274

Taurodeoxycholic acid is a taurine-conjugated form of the secondary bile acid deoxycholic acid. Acts as a useful detergent for the solubilization of lipids and membrane–bound proteins...

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Biovision | Coumestrol | B3273

Coumestrol is naturally occurring phytoestrogen. It competitively binds the estrogen receptors ERα (IC50 = 11 nM) and ERβ (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells...

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Biovision | Dichlorphenamide | B3272

Dichlorphenamide is a potent, orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively). It lowers...

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Biovision | Acetazolamide | B3271

Acetazolamide is a potent carbonic anhydrase (CA) inhibitor. It is currently used as an antiglaucoma, antiepileptic and diuretic agent, and is also effective in the treatment of Idiopathic...

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Biovision | GSK-046 | B3270

GSK-046 (iBET-BD2) is a potent and selective inhibitor of BET (bromodomain and extraterminal domain) with IC50 of 264 nM, 98 nM, 49 nM and 214 nM for BRD2BD2, BRD3BD2, BRD4BD2 and BRDTBD2,...

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Biovision | ABBV-744 | B3269

ABBV-744 is a potent BDII (Bromodomain II)-selective (>100 X selectivity over BDI) BET bromodomain inhibitor. ABBV-744 inhibits proliferation of SKM-1 leukemia cells (IC50 = 6.7 nM). It induces cell...

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Biovision | BAY-1125976 | B3268

BAY-1125976 is a potent and selective allosteric AKT1/2 inhibitor that displays high efficacy on AKT signaling-dependent tumor growth in mouse models. It inhibits Akt1 and Akt2 activity with IC50...

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Biovision | Methaneseleninic acid | B3267

Methylseleninic acid is an organoselenium compound that has a role as a human xenobiotic metabolite, histone deacetylase inhibitor and an antineoplastic agent. MSA displays anticancer activity...

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Biovision | Ganoderic Acid A | B3266

Ganoderic Acid is a triterpene found in Ganoderma mushrooms, commonly used in Traditional Chinese Medicine. Ganoderic Acid is reported to display anti-tumor activity mediated through its inhibitory...

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Biovision | Esculentoside A | B3265

Esculentoside A, isolated from the Chinese herb phytolacca esculenta, possesses a broad inhibitory effect on a panel of pro-inflammation molecules with less toxicity. It protects against...

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Biovision | Pyrimethamine | B3264

Pyrimethamine is an antiprotozoal agent that inhibits the protozoal enzyme dihydrofolate reductase (DHFR). By blocking DHFR activity, pyrimethamine prevents the production of tetrahydrofolic acid, an...

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Biovision | PRI-724 | B3263

PRI-724 (C-82 prodrug, ICG-001 analog) is a potent and specific inhibitor of the canonical Wnt signaling pathway. PRI-724 specifically inhibits the recruiting of beta-catenin with its coactivator CBP...

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Biovision | MMP Substrate, Fluorogenic | B3262

MMP substrate, Fluorogenic is a widely used FRET substrate for MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, MMP-15, and MMP-16. Also acts as a substrate for Cathepsin D and Cathepsin E...

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Biovision | N-1-Naphthylphthalamic Acid | B3261

N-1-Naphthylphthalamic Acid (NPA) is a polar auxin transport (PAT) inhibitor. It disrupts leaf initiation, KNOX protein regulation, and formation of leaf margins in maize.N-1-Naphthylphthalamic Acid...

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Biovision | BCH001 | B3260

BCH001 is a specific PAPD5 (protein arginine deiminase 5) inhibitor; it restores telomerase activity and telomere length in dyskeratosis congenita (DC) patient induced pluripotent stem cells.BCH001...

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Biovision | Methazolamide | B3259

Methazolamide is a potent carbonic anhydrase (CA) inhibitor (IC50 = 130 nM) with anti-glaucoma, anti-diabetic, and potential anti-neoplastic activity. It reduces intraocular pressure and...

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Biovision | SJA710-6 | B3258

SJA710-6 is a Hepatic Differentiation Inducer that selectively induces the differentiation of rat Mesenchymal stem cells (rMSCs) toward hepatocyte-like cells in vitro.SJA710-6 is a Hepatic...

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Biovision | ETC-159 | B3257

ETC-159 is a selective small molecule inhibitor of porcupine (PORCN), an enzyme required for palmitoylation and secretion of all Wnt ligands. It inhibits β-catenin reporter activity (IC50 = 2.9 nM)...

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Biovision | CB-103 | B3256

CB-103 acts as a potent Pan-NOTCH inhibitor by targeting NOTCH transcriptional activation complex. CB-103 blocks NOTCH signaling in human T cell acute lymphoblastic leukemia cancer cell lines and...

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Biovision | Crenigacestat | B3255

Crenigacestat (LY3039478), is a potent Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested. LY3039478 potently inhibits mutant Notch receptor activity. In a xenograft tumor...

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Biovision | CPI-455 hydrochloride | B3254

CPI-455 hydrochloride is a potent and selective inhibitor of KDM5 demethylases. which reduces survival of drug-tolerant cancer cells. CPI-455 binds to the demethylase active site and selectively...

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