Product Description
SWAP70 polyclonal Antibody | BS72678 | Bioworld
Host: Rabbit
Reactivity: Human,Mouse
Application: WB,IHC,IF
Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Background: SWAP-70 is a protein that is part of a protein complex that catalyzes cell-free DNA recombination between immunoglobulin (Ig) heavy chain gene switch region substrates. In resting B lymphocytes, SWAP-70 is localized mainly in the cytoplasm, however, in activated B cells, SWAP-70 is recruited to the plasma membrane and then translocates to the nucleus. In the nucleus, SWAP-70 recognizes specific switch regions, acting as a switch recombinase and causing a DNA break. The cellular and intracellular localization before and after B-cell activation also suggests a role for SWAP-70 in signaling in B cell activation. In addition, SWAP-70 contains three nuclear localization signals, has a weak affinity for DNA, binds ATP, and forms specific, high affinity complexes with B23, C23, and poly (ADP-ribose) polymerase.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: SWAP70 polyclonal Antibody detects endogenous levels of SWAP70 protein.
Molecular Weight: 69kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: HSPC321;SWAP-70
Immunogen: Recombinant protein of human SWAP70
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: