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![Mouse Csk Antibody (C-term) [APR17414G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/869888/1161955/logo__92149.1659788186__34699.1659865998.png?c=2 "Mouse Csk Antibody (C-term) [APR17414G]"){kind=logo}
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Product Description
Mouse Csk Antibody (C-term) [APR17414G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M, Rat
Specificity: This Mouse Csk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 398-431 amino acids from the C-terminal region of Mouse Csk.
Cellular Localisation: Cytoplasm. Cell membrane. Note=Mainly cytoplasmic, also present in lipid rafts
Molecular Weight: 50716
Clone: Polyclonal
Gene Name: Csk
Gene ID: 12988
Function: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C- terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity) .
Summary: Tissue Location: Ubiquitous, but most abundant in thymus and spleen, as well as in neonatal brain
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Tyrosine-protein kinase CSK, C-Src kinase, Protein-tyrosine kinase MPK-2, p50CSK, Csk
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