Product Description
BRAF V600E Antibody (C-Term) [APR33629G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 576-606 amino acids from human.
Cellular Localisation: Nucleus. Cytoplasm. Cell membrane. Note=Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes.
Molecular Weight: 84437
Clone: Polyclonal
Gene Name: BRAF (HGNC:1097)
Gene ID: 673
Function: Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable) . Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed:21441910, PubMed:29433126) . May play a role in the postsynaptic responses of hippocampal neurons (PubMed:1508179) .
Summary: Tissue Location: Brain and testis.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB, IHC-P
Dilution: IHC-P--1:100~500 WB--1:2000
Synonyms: Serine/threonine-protein kinase B-raf, 2.7.11.1, Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1, BRAF, BRAF1, RAFB1