Product Description
KCNJ11 Antibody | 15-407 | ProSci
Host: Rabbit
Reactivity: Human, Mouse
Homology: N/A
Immunogen: A synthetic peptide of human KCNJ11
Research Area: Cancer, Neuroscience, Signal Transduction
Tested Application: WB, Flow
Application: WB: 1:500 - 1:2000
Flow: 1:20 - 1:50
Specificiy: N/A
Positive Control 1: Mouse heart
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Observed: 44kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, pH7.3.
Concentration: N/A
Storage Condition: Store at 4˚C. Avoid freeze / thaw cycles.
Alternate Name: KCNJ11, potassium inwardly-rectifying channel, subfamily J, member 11, BIR, HHF2, IKATP, KIR6.2, MGC133230, PHHI, TNDM3, ATP-sensitive inward rectifier potassium channel 11, beta-cell inward rectifier subunit, inwardly rectifying potassium channel KIR6.2,
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI) , an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM) , transient neonatal diabetes mellitus type 3 (TNDM3) , and permanent neonatal diabetes mellitus (PNDM) . Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.