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Reagents

A substance which is used as a chemical reaction or it is a test reactions occurs. A reagents is to measure the chemical substance is present or not because reagents is the components or a mixture. A chemical reagents works like a detectives which charged and point out the other substance in chemical reactions. For making a reagents the equal number of volumes solutions A and B use immediately and then it is used as a reagents.1.5g of ferric chloride and 2.0g of potassium thiocynate in 100 ml water to dissolve after that make saturated solution in 50% ethnol.

The reagents take action when solvents involved in the reaction which are usually called reactants but catalysts are not consumed with the reactions hence they are not reactants. Iodine is not soluble in water therefore the iodine reagents is made in dissolving the water with a helps of potassium iodide.

  • Cinacalcet hydrochloride

    Biovision | Cinacalcet hydrochloride | B3297

    Cinacalcet is a calcimimetic and an allosteric agonist of the calcium-sensing receptor. Cinacalcet increases the sensitivity of calcium-sensing receptors on chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid...

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  • Resazurin sodium

    Biovision | Resazurin sodium | B3296

    Resazurin is a blue fluorogenic dye used as a redox indicator in cell viability and proliferation assays for bacteria, yeast or mammalian cells. The blue form of the dye is irreversibly reduced by enzymes in viable cells to generate a highly...

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  • Bepridil hydrochloride

    Biovision | Bepridil hydrochloride | B3295

    Bepidril hydrochloride is a non-selective calcium channel blocker and class IV antiarrhythmic agent. Also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels; acts as a calcium sensitizer.Bepidril hydrochloride is a...

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  • BAEE

    Biovision | BAEE | B3294

    BAEE (N-α-Benzoyl-L-arginine ethyl ester) is a nonpeptide substrate of proteases and deiminases. It has been used as a substrate for the determination of trypsin activity. Additionally, BAEE has also been used as a substrate for determining the activity...

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  • BRD-5529

    Biovision | BRD-5529 | B3293

    BRD-5529 is a selective, cell-permeable CARD9-E3 ubiquitin ligase TRIM62 protein-protein interaction inhibitor (IC50 of 8.6 μM). BRD-5529 directly and selectively binds CARD9, disrupts TRIM62 recruitment, inhibits TRIM62-mediated ubiquitinylation and...

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  • GLPG-0974

    Biovision | GLPG-0974 | B3292

    GLPG-0974 is a potent FFA2 (free fatty acid receptor 2) antagonist (IC50 = 9 nM). Displays selectivity for FFA2 over FFA3. GLPG-0974 inhibits acetate-induced migration of isolated human neutrophils in buffer or plasma (IC50s = 27 and 43 nM,...

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  • (2R,6R)-Hydroxynorketamine

    Biovision | (2R,6R)-Hydroxynorketamine | B3291

    (2R,6R)-Hydroxynorketamine hydrochloride is a ketamine metabolite that enhances AMPA receptor-mediated excitatory post-synaptic potentials in the CA1 region of hippocampal slices. Decreases intracellular D-serine (a NMDA co-agonist) concentrations in...

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  • (±)-Eriodictyol

    Biovision | (±)-Eriodictyol | B3290

    (±)-Eriodictyol is a natural flavonoid with potential antioxidation activity. Eriodictyol Inhibits proliferation, metastasis and induces apoptosis of glioma cells via PI3K/Akt/NF-κB Signaling Pathway. Eriodictyol may be studied to understand its...

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  • Pinocembrin

    Biovision | Pinocembrin | B3289

    Pinocembrin is a natural product isolated from the leaves of A. zerumbet. It displays enhanced alkaline phosphatase (ALP) activity and mineralization and increased mRNA expression of osteoblast-related genes Alp and Osteocalcin (Ocn) in MC3T3-E1 cells...

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  • AZ-191

    Biovision | AZ-191 | B3288

    AZ-191 is a potent and selective DYRK1B (dual-specificity tyrosine phosphorylation-regulated kinase 1B) inhibitor (IC50 = 17 nM). AZ-191 selectively inhibits DYRK1B in vitro and in cells. DYRK1B is amplified in certain cancers and may be an oncogene...

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  • DIRK1A/1B inhibitor AnnH31

    Biovision | DIRK1A/1B inhibitor AnnH31 | B3287

    DIRK1A/1B inhibitor AnnH31 is a potent selective cell-permeable DYRK1A (IC50 =81 nM) and DYRK1B inhibitor. Off-target inhibition of CLK1 and slightly DYRK2 and HIPK2. Displays minimal inhibitory effects on monoamine oxidase A (MAO A) (IC50=3.20 µg), with...

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  • Acetohydroxamic acid

    Biovision | Acetohydroxamic acid | B3286

    Acetohydroxamic acid is a potent inhibitor of bacterial urease activity and reduces urinary ammonia levels. It inhibits the growth of struvite crystals produced by P. mirabilis in artificial urine and the growth of H. pylori in vitro (MICs = 200 and 400...

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  • LDN-192960 hydrochloride

    Biovision | LDN-192960 hydrochloride | B3285

    LDN-192960 dihydrochloride is an inhibitor of Haspin protein kinase and dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) with IC50 values of 10 and 48 nM, respectively. It displays selectivity for Haspin and DYRK2 over TRKB, CLK1,...

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  • Quetiapine hemifumarate

    Biovision | Quetiapine hemifumarate | B3284

    Quetiapine fumarate Displays antagonist activity at serotonin (5-HT2) and dopamine (D2) receptors (IC50 values are 148 and 329 nM respectively). Lacks affinity at either D1 or muscarinic receptors. Acts as an atypical antipsychotic agent.Quetiapine...

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  • SB-265610

    Biovision | SB-265610 | B3283

    SB-265610 is a potent and selective CXCR2 chemokine receptor antagonist (Kd = 2.5 nM). It does not bind to CXCR1). Inhibits CINC-induced chemotaxis and attenuates neutrophil accumulation in inflammatory lung injury in vivo.SB-265610 is a potent and...

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  • SB-225002

    Biovision | SB-225002 | B3282

    SB-225002 is a potent and selective inhibitor of chemokine receptor CXCR2 with an IC50 of 22 nM for inhibiting interleukin IL-8 binding to CXCR2; displays > 150-fold selectivity over CXCR1 receptors. SB-225002 is crucial for cancer progression and is...

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  • Eugenol

    Biovision | Eugenol | B3281

    Eugenol, the major constituent of clove oil that possesses significant antioxidant, anti-inflammatory and cardiovascular properties, in addition to analgesic and local anesthetic activity. Eugenol also acts as an inhibitor of Ebola Virus (EBOV) in vitro...

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  • Topiramate

    Biovision | Topiramate | B3280

    Topiramate is a potent antiepileptic drug with a broad spectrum of activity. Topiramate acts as an antagonist of GluK1 kainate receptors (IC50 = 0.46 μM); also acts as a positive allosteric modulator of GABAA receptor-mediated currents, inhibits Nav...

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  • Zonisamide

    Biovision | Zonisamide | B3279

    Zonisamide is a broad-spectrum sulfonamide derivative with an anticonvulsant property. Zonisamide appears to block sodium and calcium channels, thereby stabilizing neuronal membranes and suppressing neuronal hyper-synchronization. In addition, this agent...

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  • 4-CPPC

    Biovision | 4-CPPC | B3278

    4-CPPC is a potent, reversible and selective small molecule inhibitor of the pro-inflammatory protein macrophage migration inhibitory factor-2 (a.k.a. MIF-2 or D-DT) (IC50 = 27 µM). 4-CPPC displays17-fold selectivity for MIF-2 versus MIF-1. MIF-2 is...

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  • A-443654

    Biovision | A-443654 | B3277

    A-443654 is a pan-Akt inhibitor and has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM). Also acts as a DYRK1A inhibitor (IC50=10nM). Inhibits other kinases, including PRK2, MSK1 and DYRK3 at low nM range as well. Displays anticancer...

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  • Glycoursodeoxycholic acid

    Biovision | Glycoursodeoxycholic acid | B3276

    Glycoursodeoxycholic acid (GUDCA) is a glycine-conjugated form of the secondary bile acid ursodeoxycholic acid. It displays antioxidant effects in vitro in Barrett’s esophagus cells and primary cultured rat neurons. GUDCA reduces the levels of...

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  • Sodium tauroursodeoxycholate

    Biovision | Sodium tauroursodeoxycholate | B3275

    Tauroursodeoxycholic acid (TUDCA) is a taurine-conjugated form of the secondary bile acid ursodeoxycholic acid. TUDCA is found in small quantities in human bile but at a higher concentration in the bile of black bears. It acts as an endoplasmic reticulum...

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  • Sodium taurodeoxycholate

    Biovision | Sodium taurodeoxycholate | B3274

    Taurodeoxycholic acid is a taurine-conjugated form of the secondary bile acid deoxycholic acid. Acts as a useful detergent for the solubilization of lipids and membrane–bound proteins. Taurodeoxycholic acid stimulates chloride ion secretion through...

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  • Coumestrol

    Biovision | Coumestrol | B3273

    Coumestrol is naturally occurring phytoestrogen. It competitively binds the estrogen receptors ERα (IC50 = 11 nM) and ERβ (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells. Coumestrol also acts as a weak antagonist of pregnane X...

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  • Dichlorphenamide

    Biovision | Dichlorphenamide | B3272

    Dichlorphenamide is a potent, orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively). It lowers intraocular pressure in rabbits when 50 µl of a 10% solution...

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  • Acetazolamide

    Biovision | Acetazolamide | B3271

    Acetazolamide is a potent carbonic anhydrase (CA) inhibitor. It is currently used as an antiglaucoma, antiepileptic and diuretic agent, and is also effective in the treatment of Idiopathic intracranial hypertension (IIH). Modulates epileptiform...

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  • GSK-046

    Biovision | GSK-046 | B3270

    GSK-046 (iBET-BD2) is a potent and selective inhibitor of BET (bromodomain and extraterminal domain) with IC50 of 264 nM, 98 nM, 49 nM and 214 nM for BRD2BD2, BRD3BD2, BRD4BD2 and BRDTBD2, respectively. GSK-046 displays immunomodulatory activity.GSK-046...

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  • ABBV-744

    Biovision | ABBV-744 | B3269

    ABBV-744 is a potent BDII (Bromodomain II)-selective (>100 X selectivity over BDI) BET bromodomain inhibitor. ABBV-744 inhibits proliferation of SKM-1 leukemia cells (IC50 = 6.7 nM). It induces cell cycle arrest at the G1 phase in LNCaP prostate cancer...

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  • BAY-1125976

    Biovision | BAY-1125976 | B3268

    BAY-1125976 is a potent and selective allosteric AKT1/2 inhibitor that displays high efficacy on AKT signaling-dependent tumor growth in mouse models. It inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively...

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  • Methaneseleninic acid

    Biovision | Methaneseleninic acid | B3267

    Methylseleninic acid is an organoselenium compound that has a role as a human xenobiotic metabolite, histone deacetylase inhibitor and an antineoplastic agent. MSA displays anticancer activity against breast cancer by inhibiting the Janus kinase 2/signal...

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  • Ganoderic Acid A

    Biovision | Ganoderic Acid A | B3266

    Ganoderic Acid is a triterpene found in Ganoderma mushrooms, commonly used in Traditional Chinese Medicine. Ganoderic Acid is reported to display anti-tumor activity mediated through its inhibitory effect on NFKB and AP-1 as well as antimetastasis and...

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  • Esculentoside A

    Biovision | Esculentoside A | B3265

    Esculentoside A, isolated from the Chinese herb phytolacca esculenta, possesses a broad inhibitory effect on a panel of pro-inflammation molecules with less toxicity. It protects against osteoarthritis by ameliorating inflammation and repressing...

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  • Pyrimethamine

    Biovision | Pyrimethamine | B3264

    Pyrimethamine is an antiprotozoal agent that inhibits the protozoal enzyme dihydrofolate reductase (DHFR). By blocking DHFR activity, pyrimethamine prevents the production of tetrahydrofolic acid, an essential coenzyme involved in DNA and RNA synthesis...

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  • PRI-724

    Biovision | PRI-724 | B3263

    PRI-724 (C-82 prodrug, ICG-001 analog) is a potent and specific inhibitor of the canonical Wnt signaling pathway. PRI-724 specifically inhibits the recruiting of beta-catenin with its coactivator CBP (the binding protein of the cAMP response...

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  • MMP Substrate, Fluorogenic

    Biovision | MMP Substrate, Fluorogenic | B3262

    MMP substrate, Fluorogenic is a widely used FRET substrate for MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, MMP-15, and MMP-16. Also acts as a substrate for Cathepsin D and Cathepsin E. Upon cleavage by MMPs, 7-methoxycoumarin-4-acetyl...

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  • N-1-Naphthylphthalamic Acid

    Biovision | N-1-Naphthylphthalamic Acid | B3261

    N-1-Naphthylphthalamic Acid (NPA) is a polar auxin transport (PAT) inhibitor. It disrupts leaf initiation, KNOX protein regulation, and formation of leaf margins in maize.N-1-Naphthylphthalamic Acid (NPA) is a polar auxin transport (PAT) inhibitor. It...

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  • BCH001

    Biovision | BCH001 | B3260

    BCH001 is a specific PAPD5 (protein arginine deiminase 5) inhibitor; it restores telomerase activity and telomere length in dyskeratosis congenita (DC) patient induced pluripotent stem cells.BCH001 is a specific PAPD5 (protein arginine deiminase 5)...

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  • Methazolamide

    Biovision | Methazolamide | B3259

    Methazolamide is a potent carbonic anhydrase (CA) inhibitor (IC50 = 130 nM) with anti-glaucoma, anti-diabetic, and potential anti-neoplastic activity. It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma.Methazolamide...

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  • SJA710-6

    Biovision | SJA710-6 | B3258

    SJA710-6 is a Hepatic Differentiation Inducer that selectively induces the differentiation of rat Mesenchymal stem cells (rMSCs) toward hepatocyte-like cells in vitro.SJA710-6 is a Hepatic Differentiation Inducer that selectively induces the...

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  • ETC-159

    Biovision | ETC-159 | B3257

    ETC-159 is a selective small molecule inhibitor of porcupine (PORCN), an enzyme required for palmitoylation and secretion of all Wnt ligands. It inhibits β-catenin reporter activity (IC50 = 2.9 nM) and reduces the interaction of Wnt with its carrier...

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  • CB-103

    Biovision | CB-103 | B3256

    CB-103 acts as a potent Pan-NOTCH inhibitor by targeting NOTCH transcriptional activation complex. CB-103 blocks NOTCH signaling in human T cell acute lymphoblastic leukemia cancer cell lines and displays anti-tumor efficacy in GSI resistant T-ALL cell...

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  • Crenigacestat

    Biovision | Crenigacestat | B3255

    Crenigacestat (LY3039478), is a potent Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested. LY3039478 potently inhibits mutant Notch receptor activity. In a xenograft tumor model, LY3039478 inhibited N1ICD cleavage and expression...

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  • CPI-455 hydrochloride

    Biovision | CPI-455 hydrochloride | B3254

    CPI-455 hydrochloride is a potent and selective inhibitor of KDM5 demethylases. which reduces survival of drug-tolerant cancer cells. CPI-455 binds to the demethylase active site and selectively inhibits KDM5A-D (IC50s = 2-10 nM) over KDM2-4, 6, and 7...

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  • A-196

    Biovision | A-196 | B3252

    A-196 is a potent and selective SUV420H1/H2 inhibitor (IC50 values are 25 and 144 nM respectively). Displays 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits the di- and tri-methylation of H4K20me in...

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  • BCI-121

    Biovision | BCI-121 | B3251

    BCI-121 is a substrate-competitive SMYD3 inhibitor that reduces nuclear histone H3 lys4 di- and tri-methylation level, downregulates known SMYD3 target genes transcription, and selectively affects SMYD3-dependent proliferation of cancer cultures with...

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  • CM-272

    Biovision | CM-272 | B3250

    CM-272 is a potent, selective, substrate-competitive and reversible dual G9a/DNA methyltransferases (DNMTs) inhibitor. CM-272 inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP with IC50s of 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively. CM-272 inhibits...

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  • Bobcat339 (free base)

    Biovision | Bobcat339 (free base) | B3249

    Bobcat339 is a potent cytosine-based TET (ten-eleven translocation methylcytosine dioxygenase) enzyme inhibitor with IC50 of 33 µM (TET1) and 73 µM (TET2). Bobcat339 does not inhibit the DNA methyltransferase, DNMT3a. Bobcat339 can reduce DNA...

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  • CIL56

    Biovision | CIL56 | B3248

    CIL56 is a small molecule that acts as a selective ferroptosis inducer through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation of long-chain saturated, monounsaturated, and polyunsaturated fatty acids in...

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  • TED-347

    Biovision | TED-347 | B3247

    TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 μM for TEAD4⋅Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central...

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  • GW-806742X

    Biovision | GW-806742X | B3246

    GW-806742X is a potent MLKL (Mixed Lineage Kinase Domain-Like protein) inhibitor, as well as a human and murine necroptosis inhibitor. GW806742X binds the MLKL pseudokinase domain with a Kd value of 9.3 μM and displays anti-necroptosis activity...

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