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Reagents

A substance which is used as a chemical reaction or it is a test reactions occurs. A reagents is to measure the chemical substance is present or not because reagents is the components or a mixture. A chemical reagents works like a detectives which charged and point out the other substance in chemical reactions. For making a reagents the equal number of volumes solutions A and B use immediately and then it is used as a reagents.1.5g of ferric chloride and 2.0g of potassium thiocynate in 100 ml water to dissolve after that make saturated solution in 50% ethnol.

The reagents take action when solvents involved in the reaction which are usually called reactants but catalysts are not consumed with the reactions hence they are not reactants. Iodine is not soluble in water therefore the iodine reagents is made in dissolving the water with a helps of potassium iodide.

  • IPG-1 AM

    Biovision | IPG-1 AM | B3140

    IPG-1 is a yellow-green fluorescent, intracellular potassium (K⁺) indicator for measuring changes at most intracellular K⁺ concentrations. It is a small, synthetic fluorochrome which incorporates a K⁺-binding moiety. When K⁺ binds, the quenching is...

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  • NCC007

    Biovision | NCC007 | B3139

    NCC007 is an inhibitor of casein kinase I (CKI) and a modulator of circadian rhythm. It inhibits CKIα and CKIδ with an IC₅₀ of 1.8 and 3.6 μM. It shows stronger period effects (0.32 μM for 5 h period lengthening) in a cell-based circadian assay.NCC007 is...

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  • ING-2 TMA+ Salt

    Biovision | ING-2 TMA+ Salt | B3138

    ING-2 is a yellow-green fluorescent intracellular sodium Na⁺ indicator. It is a small, synthetic fluorochrome fused with a Na⁺-binding moiety. When Na⁺ binds to ING-2, the quenching is relieved, and the fluorescence dramatically increases. The spectral...

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  • ING-2 AM

    Biovision | ING-2 AM | B3137

    ING-2 AM is the membrane permeable form of the sodium indicator ING-2 (Cat. No. B3138). Masking the negative charge using non-polar, ester-linked moieties (AM ester) allows the molecule to enter cells through passive diffusion. Once inside the cell,...

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  • Longdaysin

    Biovision | Longdaysin | B3136

    Longdaysin is a potent modulator of circadian rhythm. It slows the circadian clock both in cultured mammalian cells and zebrafish. It inhibits the protein kinases CKIδ, CKIα, ERK2, and CDK7 activities with IC₅₀ values of 8.8 µM, 5.6 µM, 52 µM and 29 µM,...

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  • BMS-P5

    Biovision | BMS-P5 | B3135

    BMS-P5 is a potent and selective inhibitor of peptidylarginine deiminase 4 (PAD4). It significantly reduces Multiple myeloma-cells induced citrullination of histone H3 and formation of neutrophil extracellular trap at a concentration of 1 μM. It delays...

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  • 4-Aminonaphthalimide

    Biovision | 4-Aminonaphthalimide | B3134

    4-Aminonaphthalimide is an inhibitor of poly(ADP-ribose) polymerase (PARP). It inhibits PARP with an IC₅₀ of 180 nM. It inhibits radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation.4-Aminonaphthalimide is an inhibitor of...

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  • 3-Cyano-7-ethoxycoumarin

    Biovision | 3-Cyano-7-ethoxycoumarin | B3133

    3-Cyano-7-ethoxycoumarin is a fluorogenic substrate for cytochrome P450. It is metabolized to 3-cyano-7-hydroxycoumarin with an excitation/emission maxima of 408/450 nm, respectively. It can be used to quantify the activity of cytochrome P450-dependent...

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  • 3,6-Dihydroxyflavone

    Biovision | 3,6-Dihydroxyflavone | B3132

    3,6-Dihydroxyflavone is a flavanoid which shows anticancer activity. It suppresses breast carcinogenesis by upregulation of miR-34a and downregulation of miR-21 at a concentration of 20 μM.3,6-Dihydroxyflavone is a flavanoid which shows anticancer...

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  • Penicillin G Potassium

    Biovision | Penicillin G Potassium | B3131

    Penicillin is a broad-spectrum β-lactam antibiotic. It binds to penicillin binding proteins (PBP). PBP catalyzes the synthesis of peptidoglycan, which is an important component of the bacterial cell wall. PBP catalyzes a pentaglycine crosslink between...

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  • 2-Guanidinobenzimidazole

    Biovision | 2-Guanidinobenzimidazole | B3130

    2-Guanidinobenzimidazole is an inhibitor of voltage-gated proton channel Hv1. It inhibits Hv1 proton conduction (10 μM-200 μM) by binding to the voltage-sensing domain. Inhibition of excessive Hv1 activity could be beneficial in ischemic stroke and...

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  • 2-Chloroadenosine

    Biovision | 2-Chloroadenosine | B3129

    2-Chloroadenosine is an adenosine receptor agonist. It binds to adenosine A1, A2A, and A3 receptors with Ki values of 300, 80, and 1900 nM, respectively. It significantly decreases seizures in a rat model.2-Chloroadenosine is an adenosine receptor...

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  • 2-Bromopalmitic acid

    Biovision | 2-Bromopalmitic acid | B3128

    2-Bromopalmitic acid is a fatty acid oxidation inhibitor. It inhibits carnitine palmitoyltransferase-1 (CPT1) and is also an inhibitor of protein palmitoylation. It significantly increases retinoic acid receptor alpha (RARα) protein level at a...

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  • 1-EBIO

    Biovision | 1-EBIO | B3127

    1-EBIO is an activator of Ca2+- and cAMP-sensitive K+ channels. It stimulates a sustained Cl- secretory response with an EC₅₀ of 490 μM. It induces cardiogenesis of pluripotent stem cells.1-EBIO is an activator of Ca2+- and cAMP-sensitive K+ channels. It...

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  • IM156

    Biovision | IM156 | B3126

    IM156 is a bioenergetic biguanide derivative which blocks mitochondrial complex I and an activator of AMP-activated protein kinase (AMPK). It is a derivative of metformin. IM156 causes energy depletion in tumor cells by inhibiting oxidative...

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  • TVB-2640

    Biovision | TVB-2640 | B3125

    TVB-2640 is an oral, selective fatty acid synthase (FASN) inhibitor. It reduces hepatic de novo lipogenesis in males with metabolic abnormalities. It is being evaluated in phase 2 clinical trials to treat KRAS mutant non-small cell lung carcinomas...

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  • AZD-4205

    Biovision | AZD-4205 | B3124

    AZD-4205 is a highly selective Janus Kinase 1 (JAK1) inhibitor with an IC₅₀ of 0.07 μM. It shows antitumor activity in combination with the EGFR inhibitor, osimertinib, in a preclinical non-small-cell lung cancer xenograft NCI-H1975 model. It targets...

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  • 1,4-DPCA

    Biovision | 1,4-DPCA | B3123

    1,4-DPCA is a competitive inhibitor of prolyl 4-hydroxylase. It inhibits isolated chick prolyl 4-hydroxylase and procollagen synthesis in human foreskin fibroblasts with an IC₅₀ value of 3.6 and 2.4 µM, respectively. It also inhibits factor inhibiting...

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  • 1,10-Phenanthroline

    Biovision | 1,10-Phenanthroline | B3122

    1,10-Phenanthroline is a metal chelator and inhibitor of metalloproteases. 1,10-Phenanthrine acts as a fungistatic against P. verrucosa (MIC = 0.8 μg/ml) and inhibits zinc-induced P. verrucosa metallo-type peptidase activity in a concentration-dependent...

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  • Ponesimod

    Biovision | Ponesimod | B3121

    Ponesimod is a potent agonist of sphingosine-1-phosphate receptor 1 (S1P1) receptor. It reduces the circulating lymphocytes at a dose of 3-100 mg/kg in a rat model. It selectively activates S1P1 in a GTPγS assay with an EC₅₀ of 5.7 nM. It has been...

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  • Trilaciclib dihydrochloride

    Biovision | Trilaciclib dihydrochloride | B3120

    Trilaciclib dihydrochloride is a CDK4/6 inhibitor which reduces chemotherapy-induced myelosuppression. It induces a G1 cell-cycle arrest in CDK4/6-dependent HS68 cells with an EC₅₀ of 30 nM. It is used to reduce the frequency of chemotherapy-induced bone...

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  • Acefylline

    Biovision | Acefylline | B3119

    Acefylline is a xanthine derivative which acts as potential Peptidylarginine deiminase (PAD) activator. It increases the in vitro deimination of filaggrin by PAD1 and PAD3 at a concentration of 200 μM. It enhances deimination in the stratum corneum which...

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  • Fluvoxamine Maleate

    Biovision | Fluvoxamine Maleate | B3118

    Fluvoxamine is an inhibitor of 5-hydroxytryptamine (5-HT) re-uptake. It inhibits the uptake of 5-hydroxytryptamine in guinea-pig blood platelets with a pI₅₀ (the negative logarithm of the molar concentration causing 50 % inhibition) of 6.4. It also has a...

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  • Otenabant Hydrochloride

    Biovision | Otenabant Hydrochloride | B3117

    Otenabant is a novel cannabinoid type 1 (CB1) receptor antagonist. It is effective at subnanomolar concentrations at human CB1 receptors in binding and functional assays, with Ki values of 0.7 nM and 0.12 nM respectively. It reverses cannabinoid...

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  • Sarcosine

    Biovision | Sarcosine | B3116

    Sarcosine is an intermediate in the metabolism of glycine. Sarcosine is an antagonist of glycine transporter-1 (GlyT1) with an IC₅₀ value of 91 μM. It has beneficial effects in schizophrenia. Sarcosine levels are increased in metastatic prostate cancer...

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  • Perphenazine

    Biovision | Perphenazine | B3115

    Perphenazine is a dopamine receptor antagonist. It binds to Dopamine receptors D₂, D₃ and D₄ with Ki values of 0.56 nM, 0.43 nM and 28.5 nM respectively. It also binds to serotonin receptors 5-HT1A, 5-HT2A, 5-HT2C, 5-HT6 and 5-HT7 with Ki values of 421...

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  • Tiagabine hydrochloride

    Biovision | Tiagabine hydrochloride | B3114

    Tiagabine is a selective inhibitor of GABA transporter 1 (GAT-1) and a GABA uptake inhibitor. It shows an IC₅₀ of 49 nM for GAT-1 expressed in CHO cells. It reduces allodynia in a rodent model of neuropathic pain at a dose of 72.8 µmol/kg, ip. It shows...

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  • Labetalol Hydrochloride

    Biovision | Labetalol Hydrochloride | B3113

    Labetalol is a competitive antagonist of β- and α-adrenergic receptors. It is used as an antihypertensive agent. It also shows antioxidant acitivity with an IC₅₀ of 16.5 mg/L in formyl-methionyl-leucyl-phenylalanine stimulated rabbit neutrophils...

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  • Metoclopramide Hydrochloride

    Biovision | Metoclopramide Hydrochloride | B3112

    Metoclopramide is a 5-hydroxytryptamine (serotonin) 5-HT3 receptor antagonist and dopamine D2 receptor antagonist. Metoclopramide inhibits 5-HT3 receptor and Dopamine D2 receptor binding affinity with IC₅₀ values of 308 nM and 483 nM, in rat brain...

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  • UNC2250

    Biovision | UNC2250 | B3111

    UNC2250 is an inhibitor of Mer receptor tyrosine kinase. It inhibits steady-state phosphorylation of endogenous Mer with an IC₅₀ of 9.8 nM. It blocks ligand-stimulated activation of a chimeric EGFR-Mer protein. It also decreases colony-forming potential...

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  • GGTI-298 Trifluoroacetate

    Biovision | GGTI-298 Trifluoroacetate | B3110

    GGTI-298 is an inhibitor of geranylgeranyltransferase I. This enzyme transfers geranylgeranyl group to proteins containing a CAAX sequence in which X is leucine or isoleucine. GGTI-298 inhibits the growth of A549 cells with an IC₅₀ value of 4 μM. It...

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  • FPH1

    Biovision | FPH1 | B3109

    FPH1 also known as Functional Proliferation Hit 1 induces functional proliferation of hepatocytes in vitro. It promotes the maturation of well-differentiated cultures of hepatocyte-like cells (iHeps). FPH1 (20 µM) increases the area of hepatocyte...

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  • Osilodrostat

    Biovision | Osilodrostat | B3108

    Osilodrostat is a potent inhibitor of the enzymes 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2), which catalyze the final steps of cortisol and aldosterone biosynthesis, respectively, in the adrenal cortex. Osilodrostat inhibits...

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  • Opicapone

    Biovision | Opicapone | B3107

    Opicapone is a potent inhibitor of catechol-O-methyltransferase (COMT). It inhibits rat peripheral COMT with ED₅₀ values below 1.4 mg/kg up to 6 h post-administration. It is approved for use as adjunctive treatment to levodopa/carbidopa in patients with...

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  • Ripretinib

    Biovision | Ripretinib | B3106

    Ripretinib is an inhibitor of receptor tyrosine kinase (KIT) and platelet derived growth factor receptor A (PDGFRA). In vitro kinase inhibition studies show that ripretinib inhibits wild-type KIT and PDGFRA with IC₅₀ values of 3 and 3.6 nM. It is...

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  • DMSO (Anhydrous)

    Biovision | DMSO (Anhydrous) | B3105

    DMSO is a highly polar aprotic organic solvent. It is widely used to dissolve both polar and nonpolar compound. It penetrates biological membranes and is used as a vehicle for topical application of compounds. It is used in cryopreservation of cells and...

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  • GSK-923295

    Biovision | GSK-923295 | B3104

    GSK923295 is an allosteric inhibitor of CENP-E kinesin motor ATPase activity. It inhibits CENP-E microtubule-stimulated ATPase activity with a Ki of 3.2 ± 0.2 nM. It inhibits the growth of tumor cell lines with growth inhibitory activity (GI₅₀) values...

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  • AZD-2461

    Biovision | AZD-2461 | B3103

    AZD-2461 is an inhibitor of poly(ADP-ribose) polymerase (PARP). It inhibits PARP1 and PARP2 with IC₅₀ values of 5 nM and 2 nM. It has lower affinity for P-glycoprotein and suppresses the development of drug resistance.AZD-2461 is an inhibitor of...

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  • Salvianolic acid B

    Biovision | Salvianolic acid B | B3102

    Salvianolic acid B is an antioxidant and anti-inflammatory compound extracted from Salvia miltiorrhiza. It shows cardioprotective and chemopreventative properties. It shows high free radical scavenging activity with an EC₅₀ value of 1.81 μg/ml in the...

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  • Xylitol

    Biovision | Xylitol | B3101

    Xylitol is a sugar alcohol derived from xylose by reduction of the carbonyl group. It is used as a food additive and sugar substitute. It is found in many fruits and vegetables. It is added to some dental products to prevent tooth decay.Xylitol is a...

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  • TEMPOL

    Biovision | TEMPOL | B3100

    TEMPOL is a piperidine nitroxide and spin label with superoxide dismutase (SOD) mimetic activity. It is a membrane permeable, free radical scavenger. It inhibits lipid peroxidation induced by iron plus NADPH, iron plus ascorbate, and...

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  • Digoxigenin

    Biovision | Digoxigenin | B3099

    Digoxigenin is the aglycone of digoxin. It is commonly used as a non-radioactive labeling reagent for the detection of RNA, DNA and proteins. Digoxigenin-labeled probes are used in situ hybridization as an alternative to radiolabeled probes and are...

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  • ML133 Hydrochloride

    Biovision | ML133 Hydrochloride | B3097

    ML133 is an inward-rectifier potassium channel 2 (Kir2) inhibitor. It inhibits Kir2.1 with an IC₅₀ of 1.8 μM at pH 7.4 and 290 nM at pH 8.5. It is selective for Kir2 channels over Kir1.1 and Kir4.1 channels (IC₅₀ values of 300 and 76 µM, respectively)...

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  • Lexibulin

    Biovision | Lexibulin | B3096

    Lexibulin is an orally available inhibitor of microtubule polymerization with an IC₅₀ of 3 µM. It blocks cell cycle at the G2-M phase, which leads to cell death. It is cytotoxic to various cell lines with IC₅₀ values ranging from 10-100 nM. It shows...

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  • (−)-Huperzine A

    Biovision | (−)-Huperzine A | B3095

    (−)-Huperzine A is a potent and reversible inhibitor of acetylcholinesterase. It shows an IC₅₀ value of 82 nM against acetylcholinesterase in the rat cortex in vitro. It also acts as an antagonist of the N-methyl-D-aspartate (NMDA) receptor and inhibits...

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  • Galantamine Hydrobromide

    Biovision | Galantamine Hydrobromide | B3094

    Galantamine is an alkaloid originally isolated from the bulbs and flowers of various Galanthus species. It inhibits acetylcholinesterase with an IC₅₀ of 800 nM. It is a potent allosteric potentiating ligand of human α₃β₄, α₄β₂ and α₆β₄ nicotinic...

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  • Rivastigmine tartrate

    Biovision | Rivastigmine tartrate | B3093

    Rivastigmine is a cholinesterase (ChE) inhibitor that inhibits butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) with IC₅₀ values of 0.037 μM and 4.15 μM respectively. It is used for the treatment of dementia in Alzheimer's disease and...

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  • Donepezil Hydrochloride

    Biovision | Donepezil Hydrochloride | B3092

    Donepezil is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ value of 5.7 nM. It produces a significant increase in acetylcholine content in rat cerebral cortex at a dose of 5 mg/kg (po). It is used for treating Alzheimer’s disease.Donepezil...

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  • Chlorprothixene hydrochloride

    Biovision | Chlorprothixene hydrochloride | B3091

    Chlorprothixene is a thioxanthine antipsychotic drug. It is an antagonist of dopamine and histamine receptors with Ki values of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. It also binds to serotonin...

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  • Pentylenetetrazole

    Biovision | Pentylenetetrazole | B3090

    Pentylenetetrazole is a circulatory and respiratory stimulant. It is a central nervous system modulator used to experimentally induce seizures in animals. It acts as an antagonist of GABAa receptors at IC₅₀ values of 0.6-2.2 mM.Pentylenetetrazole is a...

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  • Metergoline

    Biovision | Metergoline | B3088

    Metergoline is a serotonin (5-HT) receptor antagonist. It is active at 5-HT1 (pKi=7.8 for 5-HT1B), 5-HT2 (pKi=8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C respectively) and 5-HT7 (pKi=16 nM) receptor subtypes. Metergoline potently inhibits 5-HT...

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