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Product Description
CPI-1205 is a highly potent (biochemical IC₅₀ = 0.002 μM, cellular EC50 = 0.032 μM) and selective inhibitor of the histone lysine methyltransferase EZH2 (biochemical IC₅₀ = 0.002 μM, cellular EC₅₀ = 0.032 μM). Upon oral administration, CPI-1205 selectively inhibits the activity of both wild-type and mutated forms of EZH2.
CPI-1205 is a highly potent (biochemical IC₅₀ = 0.002 μM, cellular EC50 = 0.032 μM) and selective inhibitor of the histone lysine methyltransferase EZH2 (biochemical IC₅₀ = 0.002 μM, cellular EC₅₀ = 0.032 μM). Upon oral administration, CPI-1205 selectively inhibits the activity of both wild-type and mutated forms of EZH2.
Biovision | B2509 | CPI-1205 DataSheet
Alternate Name/Synonyms: N-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-2-methyl-1-[(1R)-1-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]ethyl]indole-3-carboxamide; CPI1205
Appearance: Crystalline solid
Formulation:
CAS Number: 1621862-70-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₇H₃₃F₃N₄O₃
Molecular Weight: 518.57
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: >100 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An EZH2 inhibitor
MDL Number:
PubChem CID: 78320408
SMILES: CC1=CC(=C(C(=O)N1)CNC(=O)C2=C(N(C3=CC=CC=C32)C(C)C4CCN(CC4)CC(F)(F)F)C)OC
InChi: InChI=1S/C27H33F3N4O3/c1-16-13-23(37-4)21(25(35)32-16)14-31-26(36)24-18(3)34(22-8-6-5-7-20(22)24)17(2)19-9-11-33(12-10-19)15-27(28,29)30/h5-8,13,17,19H,9-12,14-15H2,1-4H3,(H,31,36)(H,32,35)/t17-/m1/s1
InChi Key: HPODOLXTMDHLLC-QGZVFWFLSA-N
