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Product Description
Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
Biovision | 6716 | PCSK9 Antibody DataSheet
Antibody Target: PCSK-9
Target Alternative Name: PCSK9, FH3, HCHOLA3, LDLCQ1, NARC1, PC9, FH3; NARC-1; HCHOLA3; PC9; Proprotein convertase 9; Subtilisin/kexin-like protease PC9; Hypercholesterolemia, autosomal dominant 3; Neural apoptosis-regulated convertase 1;
Tag Line: Polyclonal Antibody to detect PCSK9 in human samples.
Category: PCSK9
Host: Rabbit
Isotype: Rabbit IgG
Species Reactivities: Human
Immunogen Sequence: A synthetic peptide corresponding to a sequence at the C-terminal (671-687aa AVTAVAICCRSRHLAQA) of human PCSK9.
Accession #: Q8NBP7
Gene ID: 255738
Appearance: Lyophilized powder
Form: Liquid
Concentration: N/A
Formulation: Lyophilized from 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal and 0.05 mg NaN3.
Purification: Immunogen affinity purified.
Application: WB, IHC-P
Positive Control: Western blot: A549, HeLa, U87, PANC Cell Lysate. IHC-P: Human Intestinal Cancer Tissue.
Application And Usages: WB, IHC-P
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: Verified
Immunocytochemistry Verified: Verified
Immunofluorescence Verified: Not Verified
Immunoprecipitation Verified: Not Verified
FACS Verified:
ELISA Verified: Not Verified
ChIP Verified: Not Verified
Dot Blot Verified:
Flow Cytometry Verified: Not Verified
