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Biochemicals

  • RA-9

    Biovision | RA-9 | B3358

    Biovision | RA-9 | B3358Description: RA-9 is a potent and selective proteasome-associated deubiquitinating enzymes (DUBs) inhibitor that displays favorable toxicity profile and anticancer activity. RA-9 blocks ubiquitin-dependent protein degradation...

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  • AS-1517499

    Biovision | AS-1517499 | B3357

    Biovision | AS-1517499 | B3357Description: AS-1517499 is a potent and brain-permeable STAT6 phosphorylation inhibitor (IC50 = 21 nM). It inhibits IL-4-induced Th2 differentiation (IC50 = 2.3 nM), but not IL-12-induced Th1 differentiation, of mouse spleen...

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  • SAR-407899  free bas

    Biovision | SAR-407899  free base | B335

    Biovision | SAR-407899  free base | B3356Description: SAR-407899 is a potent and selective Rho kinase (ROCK) inhibitor with potential antihypertensive activity. SAR-407899 is equipotent against human and rat-derived Rho-kinase 2 with IC50 values of 36 nM...

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  • S107 free base

    Biovision | S107 free base | B3354

    Biovision | S107 free base | B3354Description: S107 is a Type 1 ryanodine receptor (RyR1) stabilizer that binds RyR1 and enhances the binding affinity of calstabin-1. The intracellular Ca2+ leak was significantly reduced in mice treated with S107...

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  • PPQ-102

    Biovision | PPQ-102 | B3353

    Biovision | PPQ-102 | B3353Description: PPQ -102 is a potent, voltage-independent CFTR chloride channel inhibitor (IC50 = 90 nM). PPQ-102 displays nephroprotective and anti-fibrotic activities, decreasing the size of pre-formed kidney cysts in animal...

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  • XL-147

    Biovision | XL-147 | B3352

    Biovision | XL-147 | B3352Description: XL-147 is a potent and reversible Class 1 PI3-kinase family inhibitor with potential antineoplastic activity. Inactivation of PI3K has been shown to inhibit growth and induce apoptosis (programmed cell death) in...

    $234.00 - $749.00
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  • Tangeretin

    Biovision | Tangeretin | B3350

    Biovision | Tangeretin | B3350Description: Tangeretin is a methoxyflavone compound isolated from citrus fruits that demonstrates antiproliferative and antioxidant effects. It inhibits signaling in cancer cells, reducing ERK phosphorylation and growth of...

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  • HLY78

    Biovision | HLY78 | B3349

    Biovision | HLY78 | B3349Description: HLY78 is a positive modulator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction. HLY78 activates Wnt...

    $220.00 - $693.00
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  • Resatorvid

    Biovision | Resatorvid | B3347

    Biovision | Resatorvid | B3347Description: Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively...

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  • PSN -375963

    Biovision | PSN -375963 | B3346

    Biovision | PSN -375963 | B3346Description: PSN-375963 is a potent GPR119 agonist, with EC50s of 8.4 and 7.9 μM for human and mouse GPR119, respectively. GPR119 that shows similar potency to oleoyl ethanolamide (OEA) at both recombinant mouse and human...

    $220.00 - $693.00
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  • CAY-10698

    Biovision | CAY-10698 | B3345

    Biovision | CAY-10698 | B3345Description: CCAY-10698 is an inhibitor of 12-LO (12-lipoxygenase) with an IC50 value of 5.1 µM. It displays weaker potency for 15-LO-1, 15-LO-2, and 5-LO (IC50s = >50, >40, and >200 µM.Alternate Name/Synonyms:...

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  • 8-Prenylnarinegin

    Biovision | 8-Prenylnarinegin | B3344

    Biovision | 8-Prenylnarinegin | B3344Description: 8-Prenylnaringenin (8-PN) is a non-steroidal phytoestrogen from Hops that mimicks endogenous estrogens via estrogen receptor binding. Inhibits both isoforms of the human estrogen receptor (ER; IC50s =...

    $150.00 - $414.00
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  • AS-1842856

    Biovision | AS-1842856 | B3343

    Biovision | AS-1842856 | B3343Description: AS-1842856 is a potent and selective Foxo1 (forkhead box class O transcription factor 1) inhibitor (IC50 values are 33 nM at Foxo1 and >1 μM at Foxo3a and Foxo4); decreases Foxo-mediated promoter activity by...

    $164.00 - $442.00
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  • AH10639 phosphate

    Biovision | AH10639 phosphate | B3342

    Biovision | AH10639 phosphate | B3342Description: AH10639 phosphate is a novel inhibitor of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase. AH10639 is significantly more potent and selective than pyrimethamine as an inhibitor of T...

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  • 5-LO Inhibitor, CDC

    Biovision | 5-LO Inhibitor, CDC | B3341

    Biovision | 5-LO Inhibitor, CDC | B3341Description: CDC is a potent and direct inhibitor of 5-LO (5-lipoxygenase). CDC reduces 5-LO activity in cell-free assays (purified human recombinant enzyme or leukocyte homogenates), with IC50 values in the low...

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  • Puerarin

    Biovision | Puerarin | B3374

    Biovision | Puerarin | B3374Description: Puerarin is the major bioactive ingredient isolated from the root of the Pueraria lobata (Willd.) It has been widely used in the treatment of cardiovascular and cerebrovascular diseases, diabetes and diabetic...

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  • PKF118-310

    Biovision | PKF118-310 | B3373

    Biovision | PKF118-310 | B3373Description: PKF118-310 is an antagonist of the Tcf4/b-catenin signaling. It disrupts binding of β-catenin to a GST-Tcf4 fusion protein in HCT116 cell lysates (IC50 = 0.8 µM). PKF118-310 inhibits expression of survivin and...

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  • Baicalin

    Biovision | Baicalin | B3372

    Biovision | Baicalin | B3372Description: Baicalin is a biologically active flavonoid compound that displays anti-inflammatory and anti-oxidant activity. Baicalin inhibits HIV-1 replication by blocking the activity of the reverse transcriptase (HIV-1 RT)...

    $150.00 - $414.00
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  • AUDA

    Biovision | AUDA | B3371

    Biovision | AUDA | B3371Description: AUDA is an inhibitor of soluble epoxide hydrolase (sEH) (displaying IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively. Produces a hypotensive effect in angiotensin-infused rats and prevents and...

    $164.00 - $470.00
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  • Albiflorin

    Biovision | Albiflorin | B3370

    Biovision | Albiflorin | B3370Description: Albiflorin, a major constituent isolated from Peony roots, is a monoterpene glycoside with neuroprotective effects. It acts as a novel 5-HT and NE (norepinephrine) reuptake inhibitor with high selectivity...

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  • Dexrazoxane

    Biovision | Dexrazoxane | B3369

    Biovision | Dexrazoxane | B3369Description: Dexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα. Dexrazoxane could chelate iron to decrease the generation of ROS, thus preventing ROS-induced cardiomyocyte apoptosis...

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  • ARV-771

    Biovision | ARV-771 | B3368

    Biovision | ARV-771 | B3368Description: ARV-771 is a potent BET bromodomain PROTAC® degrader with Kds of 34 nM, 4.7 nM, 8.3 nM, 7.6 nM, 9.6 nM, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively. Degrades BRD2/3/4 in...

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  • A-317491

    Biovision | A-317491 | B3367

    Biovision | A-317491 | B3367Description: A-317491 is a selective non-nucleotide antagonist of P2X3 and P2X2/3 receptor activation. A-317491 potently blocks recombinant human and rat P2X3 and P2X2/3 receptor-mediated calcium flux (Ki = 22-92 nM) and is...

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  • Ch 55

    Biovision | Ch 55 | B3366

    Biovision | Ch 55 | B3366Description: Ch 55 is a synthetic retinoid that has high affinity for RAR-α and RAR-β receptors and low affinity for cellular retinoic acid binding protein (CRABP). Ch 55 inhibits squamous cell differentiation of rabbit tracheal...

    $275.00 - $888.00
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  • Risedronate sodium

    Biovision | Risedronate sodium | B3365

    Biovision | Risedronate sodium | B3365Description: Risedronate (risedronic acid), is an orally administered pyridinyl bisphosphonate that inhibits osteoclast-mediated resorption of bone and modulates bone metabolism in women with postmenopausal...

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  • Isorhamnetin

    Biovision | Isorhamnetin | B3364

    Biovision | Isorhamnetin | B3364Description: Isorhamnetin is a natural flavonol aglycone that displays antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 µM). It also competitively inhibits the human multidrug and toxic compounds extrusion...

    $220.00 - $693.00
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  • Medicarpin

    Biovision | Medicarpin | B3363

    Biovision | Medicarpin | B3363Description: Medicarpin is a pterocarpan class of naturally occurring benzopyran furanobenzene compound. In calvarial osteoblasts, medicarpin blocks nuclear factor kappaB (NF-κB) signaling assessed by tumor necrosis factor...

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  • SC-75741

    Biovision | SC-75741 | B3361

    Biovision | SC-75741 | B3361Description: SC-75741 is a potent NF-κB inhibitor (EC50 = 200 nM) that efficiently blocks influenza virus propagation. The mechanism of SC-75741 action involves impaired DNA binding of the NF-κB subunit p65, resulting in...

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  • TCS-1102

    Biovision | TCS-1102 | B3360

    Biovision | TCS-1102 | B3360Description: TCS-1102 is a potent, brain-permeable dual orexin receptor antagonist (Ki values are 0.2 and 3 nM for OX2 and OX1 receptors respectively. It is a poor substrate for P-glycoprotein and, as a result, demonstrates...

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  • YM-254890

    Biovision | YM-254890 | B3393

    Biovision | YM-254890 | B3393Description: YM-254890 is a cyclic depsipeptide that acts as a Gα-protein inhibitor. It potently inhibits Gq/11 heterotrimeric G protein signaling. Inhibits ATP/UTP-induced Ca2+ increase in HCAE cells expressing P2Y2 receptor...

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  • CMPD101

    Biovision | CMPD101 | B3392

    Biovision | CMPD101 | B3392Description: CMPD101 is a potent, selective and cell-permeable GRK2/3 inhibitor (IC50 values are 32 and 54 nM for GRK3 and GRK2, respectively). CMPD101 displays selectivity for GRK2/3 over GRK1/5. CMPD101 displays less...

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  • Gallein

    Biovision | Gallein | B3391

    Biovision | Gallein | B3391Description: Gallein is an inhibitor of G protein βγ subunit-dependent signaling. Blocks PI 3-kinase and Rac1 activation in HL60 cells and chemotaxis in HL60 differentiated cells. It inhibits metastatic spread of tumor cells...

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  • Tedizolid

    Biovision | Tedizolid | B3389

    Biovision | Tedizolid | B3389Description: Tedizolid is an oxazolidinone-class antibiotic. It exerts its bacteriostatic microbial activity through inhibition of protein synthesis by binding to the 50S ribosomal subunit of the bacteria.Alternate...

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  • MRX-2843

    Biovision | MRX-2843 | B3388

    Biovision | MRX-2843 | B3388Description: MRX-2843 (UNC2371) is a potent, ATP-competitive dual MERTK and FLT3 tyrosine kinases inhibitor (TKI) with enzymatic IC50s of 1.3 nM for MERTK and 0.64 nM for FLT3, respectively. It also inhibits Axl and Tyro3...

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  • YKL-05-099

    Biovision | YKL-05-099 | B3387

    Biovision | YKL-05-099 | B3387Description: YKL-05-099 is an inhibitor of the salt-inducible kinase (SIK1 and SIK3; IC50s: 10 and 30 nM, respectively). It displays less potency towards SIK2 (IC50 = 40 nM). YKL-05-099 Suppresses acute myeloid leukemia...

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  • Telotristat

    Biovision | Telotristat | B3386

    Biovision | Telotristat | B3386Description: Telotristat is an oral, small molecule inhibitor of tryptophan hydroxylase 1 (TPH1) IC50 = 16 nM) that is used in the treatment of symptoms of carcinoid syndrome.Alternate Name/Synonyms:...

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  • Isorhapontigenin

    Biovision | Isorhapontigenin | B3385

    Biovision | Isorhapontigenin | B3385Description: Isorhapontigenin is a polyphenolic compound found in Chinese herbs and grapes that displays anti-inflammatory effects. Isorhapontigenin induces autophagy and inhibits invasive bladder cancer formation. It...

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  • VAL-083

    Biovision | VAL-083 | B3384

    Biovision | VAL-083 | B3384Description: VAL-083 is a bifunctional alkylating agent with antitumor activity. Upon administration, VAL-083 crosses the blood brain barrier (BBB) and appears to be selective for tumor cells. VAL-083 alkylates and crosslinks...

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  • Conophylline

    Biovision | Conophylline | B3383

    Biovision | Conophylline | B3383 Description: Conophylline is a naturally occurring plant-based vinca alkaloid that acts as a novel differentiation inducer for pancreatic β cells; can increase the numbers of ductal cells positive for...

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  • Sulindac

    Biovision | Sulindac | B3382

    Biovision | Sulindac | B3382Description: Sulindac is non-steroidal anti-inflammatory drug (NSAID) and an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells...

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  • BNC-105

    Biovision | BNC-105 | B3381

    Biovision | BNC-105 | B3381Description: BNC-105 is a tubulin polymerization inhibitor and vascular disrupting agent (VDA) with potent antiproliferative and tumor vascular disrupting properties.Alternate Name/Synonyms:...

    $289.00 - $964.00
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  • Polydatin

    Biovision | Polydatin | B3380

    Biovision | Polydatin | B3380Description: Polydatin is a monocrystalline compound isolated from the root and rhizome of Polygonum cuspidatum Sieb. et Zucc. (Polygonaceae). It displays antioxidant and anti-inflammatory effects. Polydatin inhibits NLRP3...

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  • Ethosuximide

    Biovision | Ethosuximide | B3379

    Biovision | Ethosuximide | B3379Description: Ethosuximide is a T-type channel blocker used clinically as an antiepileptic.Alternate Name/Synonyms: Etosuximida 2-Ethyl-2-methylsuccinimide ZarontinAppearance: White to off-white solidFormulation: CAS...

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  • Emavusertib

    Biovision | Emavusertib | B3378

    Biovision | Emavusertib | B3378Description: Emavusertib is an orally bioavailable, reversible inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4), with potential antineoplastic, immunomodulating and anti-inflammatory activities. Upon oral...

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  • Etalocib

    Biovision | Etalocib | B3376

    Biovision | Etalocib | B3376Description: Etalocib (LY293111) is a potent and selective inhibitor of the lipoxygenase pathway either directly through 5'-lipoxygenase or via antagonism of the leukotriene B4 (LTB4) receptor. Etalocib (LY293111) prevents...

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