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Product Description
Rabbit Anti-Human BRCA1 (pSer1423) Polyclonal
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Size 100 µl
Target BRCA1 (pSer1423)
Conjugate FITC
Research Area Cell Signaling | Epigenetics and Nuclear Signaling | DNA/RNA | DNA Damage and Repair | BRAC1 | Cell Signaling | Epigenetics and Nuclear Signaling | Chromatin Modifying Enzymes | Chromatin Ubiquitination | Cell Signaling | Post-translational Modificat
Alternative Name BRCAI Antibody, EC:2.3.2.27 Antibody, BRCA 1 Antibody, BRCC1 Antibody, Protein phosphatase 1 regulatory subunit 53 Antibody, BRCA1 Antibody, BRCA1 DNA repair associated Antibody, FANCS Antibody, PPP1R53 Antibody, PNCA4 Antibody, Breast cancer type 1
Category Antibodies
Product Type Polyclonal Antibody
Immunogen Synthetic phospho-peptide from human BRCA1 around the phosphorylation site of serine 1423 (pSer1423).
Immunogen Species Human
Applications WB, IHC, ELISA
Host Rabbit
Isotype N/A
Species Reactivity Human, Rat
Antibody Dilution WB (1:250-1:1000); IHC (1:50-1:150); ELISA (1:2500); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Storage Buffer PBS, 50% glycerol, 0.5% BSA, 0.02% sodium azide
Concentration N/A
Specificity Detects endogenous levels of BRCA1 protein only when phosphorylated at serine 1423 (pSer1423). Detects a band at ~210 kDa.
Storage -20ºC
Shipping Blue Ice or 4ºC
Certificate of Analysis N/A
Cellular Localization Nucleus, Chromosome, Cytoplasm, Chromosome, Cytoskeleton, Gamma-Tubulin Ring Complex, Brca1-A Complex, Brca1-Bard1 Complex, Lateral Element, Nucleoplasm, Plasma Membrane, Intracellular Ribonucleoprotein Complex, Protein Complex, Ubiquitin Ligase Comp
Tissue Specificity Isoform 1 and isoform 3 are widely expressed. Isoform 3 is reduced or absent in several breast and ovarian cancer cell lines.
Accession Number NP_009225.1
Gene ID 672
Swiss-Prot P38398
Field of Use For in vitro research use only.
