Product Description
The research-grade biosimilar is a fully humanized monoclonal antibody that targets alpha and beta isoforms of calcitonin gene-related peptide (CALCA and CALCB). Calcitonin gene-related peptide (CGRP) is a neuropeptide that is released by the nerve endings of nociceptive (trigeminal) neurons. In addition to dilating meningeal vessels, CGRP causes extravasation of plasma protein and degranulation of mast cells. Degranulation of mast cells releases pro-inflammatory cytokines and causes neurogenic inflammation. Inflammation promotes sensitization of trigeminal neurons that carry the pain stimuli to the thalamus, hypothalamus, and cortex, thus resulting in migraine attacks. The antibody targets both CALCA and CALCB by inhibiting their binding to the receptor thus preventing migraine attacks. The original monoclonal antibody has been approved by the FDA to treat migraines in adults.
Biovision | A2217 | Anti-CALCA/CALCB (Eptinezumab), Humanized Antibody DataSheet
Antibody Target: CALCA/CALCB
Target Alternative Name: ALD403, CT, KC, PCT, CGRP, CALC1, CGRP1, CGRP-I, CGRP-alpha, CALC2, CGRP2, CGRP-II
Tag Line: The biosimilar is a fully humanized monoclonal antibody that targets CALCA and CALCB by blocking their binding to the receptor and prevent migraine attacks
Category: Biosimilars
Host: Recombinant
Isotype: IgG1, kappa
Species Reactivities: Human
Immunogen Sequence: Human CALCA/CALCB
Accession #: DB14040
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration: 1 mg/ml
Formulation: In PBS, pH 7.5
Purification: Protein A purified
Application:
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE