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Product Description
The research-grade biosimilar is an antibody-drug conjugate that is directed to CD22 which is highly expressed on the surface of B cells. The conjugate consists of Anti-CD22 humanized monoclonal antibody that is linked to a cytotoxic drug N-acetyl-gamma-calicheamicin via 4-(4 acetylphenoxy) butanoic acid (acetyl butyrate) linker. Upon internalization in the cell, the drug is detached from the antibody by hydrolytic cleavage. The drug binds to the minor groove of the DNA and forms a diradical species. This diradical species abstracts hydrogen ions from the phosphodiester bonds of DNA and causes double-strand DNA breaks, which leads to cell cycle arrest and apoptosis of the tumorigenic cells. The original antibody-drug conjugate is approved by the FDA to treat acute myeloid leukemia. It is also approved to treat adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL).
Biovision | A2179 | Anti-CD22 (Inotuzumab Ozogamicin), Humanized Antibody DataSheet
Antibody Target: CD22
Target Alternative Name: CMC 544, CMC-544, CMC544, PF-05208773, WAY-207294, Way 207294, SIGLEC2, SIGLEC-2
Tag Line: The biosimilar is an antibody-drug conjugate that targets CD22 that is highly expressed on the B cell surface. Upon detachment from the antibody inside the cell, the drug causes double-stranded DNA breaks, which leads to cell cycle arrest, and apoptosis of tumor cells
Category: Biosimilars
Host: Recombinant
Isotype: IgG4, kappa
Species Reactivities: Human
Immunogen Sequence: Human CD22
Accession #: DB05889
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration: 1 mg/ml
Formulation: In PBS, pH 7.5
Purification: Protein A purified
Application:
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
