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Product Description
The research-grade biosimilar is a human IgG1 kappa monoclonal antibody that targets CD38, a type II transmembrane glycoprotein that is expressed on lymphoid cells, myeloid cells, and non-hematopoietic cells and performs several cell signaling functions. It is overexpressed on multiple myeloma cells. The antibody binds to CD38 and induces tumor cell death via diverse mechanisms such as antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC) and antibody-dependent cellular phagocytosis. Antibody-dependent cellular cytotoxicity is mediated by the binding of the Fc region of the antibody with FcR of NK cells; complement-dependent cytotoxicity is mediated by the binding of the Fc region of the antibody with C1q, followed by the initiation of the complement cascade; antibody-dependent cellular phagocytosis is mediated by binding of the Fc region of the antibody with the FcR of the macrophage. The original biosimilar was approved for the treatment of multiple myeloma in 2020.
Biovision | A2319 | Anti-CD38 (Isatuximab) Humanized Antibody DataSheet
Antibody Target: Human CD38
Target Alternative Name: ADPRC1; cADPr hydrolase 1; T10; Cluster of differentiation 38; CD38 Antigen (P45)
Tag Line: A tumor biomarker that is overexpressed in multiple myeloma
Category: GM-CSF
Host: CHO cells
Isotype: IgG1-kappa
Species Reactivities: Human
Immunogen Sequence: Human CD38
Accession #: P28907
Gene ID: 952
Appearance: Liquid
Form: Humanized IgG1-kappa
Concentration:
Formulation: PBS pH 7.5
Purification:
Application:
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
