Euro
USD
British Pound
NULL
Product Description
The research-grade biosimilar is a human IgG1 monoclonal antibody that targets IL-17? and prevents its association with the receptor IL-17R. This results in decreased release of proinflammatory cytokines and chemokines and downregulation of inflammation. IL-17 represents a family of cytokines (IL-17 A-F) that is released by T-helper-17 (Th17) cells, mast cells, neutrophils, and dendritic cells and promotes inflammation. Studies show that IL-17 is associated with multiple autoimmune diseases such as rheumatoid arthritis, spondyloarthritis, psoriasis, Crohn's disease, and multiple sclerosis. The original monoclonal antibody received approval from the FDA to treat plaque psoriasis, psoriatic arthritis, and ankylosing spondylitis.
Biovision | A2154 | Anti-IL-17? (Secukinumab), Human IgG1 Antibody DataSheet
Antibody Target: IL-17?
Target Alternative Name: IL17, CTLA8, IL-17, CTLA-8, IL17A
Tag Line: The biosimilar antibody is a human monoclonal that selectively targets IL-17?, a pro-inflammatory cytokine that is highly expressed during inflammatory conditions and immune responses. The original drug received FDA approval to treat adults with moderate-to-severe plaque psoriasis, ankylosing spondylitis, and psoriasis
Category: Biosimilars
Host: Recombinant
Isotype: IgG1, kappa
Species Reactivities: Human
Immunogen Sequence: Human IL-17?
Accession #: DB09029
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration: Lot specific
Formulation: In PBS, pH 7.5
Purification: Protein A purified
Application: In vitro studies
Positive Control:
Application And Usages: In vitro studies
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
