Euro
USD
British Pound
NULL
Product Description
The research-grade biosimilar is a recombinant, fully human IgG2 kappa monoclonal antibody that binds with a high affinity to the Interleukin-17 receptor ? (IL-17R?). IL-17R is a type I membrane glycoprotein that is ubiquitously expressed on cell surfaces and binds IL17? with low affinity. IL17? plays an important role in the pathogenesis of inflammatory and autoimmune diseases such as rheumatoid arthritis. The antibody binds to the IL-17R? and inhibits IL-17 induced release of pro-inflammatory cytokines and chemokines such as NF-?B, IL-6, IL-8, COX-2, MMPs, and GM-CSF. The original drug received approval from the FDA to treat moderate-to-severe psoriasis
Biovision | A2155 | Anti-IL-17R? (Brodalumab), Human IgG2 Antibody DataSheet
Antibody Target: IL-17R?
Target Alternative Name: AMG827, KHK4827, AMG 827, AMG-827, KHK-4827, KHK4827, IL17RA, CD217
Tag Line: The biosimilar is a human monoclonal antibody that targets IL-17R? and inhibits the release of pro-inflammatory cytokines and chemokines. The original drug is approved by the FDA to treat plaque psoriasis
Category: Biosimilars
Host: Recombinant
Isotype: Human IgG2, kappa
Species Reactivities: Human
Immunogen Sequence: Human IL-17R?
Accession #: DB11776
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration: 1 mg/ml
Formulation: In PBS, pH 7.5
Purification: Protein A purified
Application:
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
