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Product Description
The research-grade biosimilar is a fully human IgG4 monoclonal antibody that targets IL-4R? and inhibits IL-4 and IL-13 signaling. Both IL-4 and IL-13 play an important role in Th-2 mediated immune response. Their inhibition leads to reduced Type 2 inflammation. The biosimilar was generated in CHO cells using recombinant DNA technology. The original monoclonal antibody received approval from the FDA for the treatment of atopic dermatitis and eczema. Additionally, this antibody received approval to treat patients aged 12 years and above, suffering from moderate-to-severe asthma, and moderate-to-severe eosinophilic asthma, or oral corticosteroid-dependent asthma.
Biovision | A2148 | Anti-IL-4R? (Dupilumab), Human IgG4 Antibody DataSheet
Antibody Target: IL-4R?
Target Alternative Name: CD124, IL4RA, IL-4RA, IL4R
Tag Line: A fully human monoclonal antibody that binds to the IL-4 receptor and inhibits receptor-mediated signaling of pro-inflammatory cytokines that play a central role in inflammatory and allergic conditions such as asthma, eczema, and rhinosinusitis
Category: Biosimilars
Host: Recombinant
Isotype: IgG4, kappa
Species Reactivities: Human
Immunogen Sequence: Human IL-4R?
Accession #: DB12159
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration: Lot specific
Formulation: In PBS, pH 7.5
Purification: Protein A purified
Application: In vitro studies
Positive Control:
Application And Usages: In vitro studies
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
