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Product Description
The research-grade biosimilar is a humanized IgG1 monoclonal antibody that selectively binds to isoleucine 61 amino acid residue in the domain 1 of IL-5R?. Binding of the antibody prevents the interaction of IL-5 with the receptor and heterodimerization of ? and ?c subunits, thus inhibiting IL-5 mediated signaling. Additionally, the antibody binds via its Fc constant region to the Fc?IIIRa receptor located on the surface of NK cells and thus induces eosinophil apoptosis via the release of proapoptotic proteins such as granzyme B and perforins. The original drug received FDA approval in 2017 to treat severe eosinophilic asthma. The US FDA also granted orphan drug designation to this drug in 2019 for the treatment of eosinophilic esophagitis
Biovision | A2162 | Anti-IL-5R? (Benralizumab), Humanized Antibody DataSheet
Antibody Target: IL-5R?
Target Alternative Name: BIW-8405, MEDI-563, KHK4563, IL5R, CD125, CDw125, HSIL5R3
Tag Line: The biosimilar is a humanized monoclonal antibody that targets IL-5R? expressed on the eosinophil and basophil cell surface, prevents the interaction of IL-5 with the receptor, and thus reduces eosinophils and basophils via antibody-dependent cell cytotoxicity
Category: Biosimilars
Host: Recombinant
Isotype: IgG1, kappa
Species Reactivities: Human
Immunogen Sequence: Human IL-5R?
Accession #: DB12023 (DB06024)
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration: 1 mg/ml
Formulation: In PBS, pH 7.5
Purification: Protein A purified
Application:
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
