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Product Description
Coronaviruses (CoV) are a large group of enveloped positive-sense RNA viruses. They belong to subfamily Coronavirinae, in the family of Coronaviridae, of the order of Nidovirales. The Coronavirus genome is about 30 kb in length and encodes four structural proteins, namely, spike (S), envelope (E), membrane (M) and nucleocapsid (N), multiple nonstructural proteins, and other accessory proteins. The Spike (S) protein is a 180 kDa type I glycosylated transmembrane protein, that assembles as a trimer on the surface of the virus, hence the coronavirus appears crown-shaped (In Latin, corona means crown). The ectodomain of the Spike protein consists of two domains: the S1 domain whose main function is receptor binding, and the S2 domain whose main function is membrane fusion. S1 binds to the cell surface receptor of the host for attachment during the viral entry, this induces a conformational change in the S2, thus enabling the fusion of host and viral membranes and ultimately entry of the viral genome in the host cell.
Biovision | A2266 | Anti-SARS-CoV-2 S1 Antibody (Clone# S309) DataSheet
Antibody Target: SARS-CoV-2 Spike S1
Target Alternative Name: Spike protein, COVID19, COVID 19, S protein, SARS-CoV S protein, S glycoprotein, E2, Peplomer protein, Spike protein S1, SARS Coronavirus, SARS-CoV-2, SARS CoV 2, 2019-nCoV, S309
Tag Line: Recombinant monoclonal antibody (Clone# S309) to detect SARS-CoV-2 Spike S1 protein
Category: Primary antibody
Host: Recombinant
Isotype: Human IgG1
Species Reactivities: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), SARS-CoV
Immunogen Sequence: Recombinant SARS-CoV-2 RBD protein
Accession #:
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration:
Formulation: In PBS, pH 7.5
Purification:
Application: ELISA
Positive Control:
Application And Usages: ELISA 1:5000-1:10,000
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: TRUE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
