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Product Description
The Spike protein (S) is a type I membrane fusion protein required for viral infection and pathogenesis. It is synthesized as a precursor protein between 1200 to 1300 amino acids. The mature protein is a heavily glycosylated trimer with 21-35 glycosylation sites. Upon cleavage by host proteases, it yields 2 subunits, S1 and S2. The S1 subunit consists of 672 amino acids and is divided into 4 domains: an N-terminal domain, a C-terminal domain (also called receptor binding domain, RBD), and 2 subdomains SD1 and SD2. The S2 subunit consists of 588 amino acids and is divided into 4 domains: an N-terminal hydrophobic fusion peptide (FP), 2 heptad repeats (HR1 and HR2), a transmembrane domain (TM), and a cytoplasmic tail. When S1 recognizes and binds to the host receptor, the S2 subunit undergoes a conformational change to bring about the fusion of viral envelope and host cell membrane. Current strategies involve the development of anti-viral drugs to inhibit infection of coronavirus.
Biovision | A2269 | Anti-SARS-CoV-2 Spike (NTD) Antibody (Clone# 4A8) DataSheet
Antibody Target: SARS-CoV-2 Spike protein NTD
Target Alternative Name: Spike protein, COVID19, COVID 19, S protein, SARS-CoV S protein, S glycoprotein, E2, Peplomer protein, Spike protein S1, SARS Coronavirus, SARS-CoV-2, SARS CoV 2, 2019-nCoV, Spike protein S2, S2 protein, NTD, N-terminal domain, 4A8
Tag Line: Recombinant monoclonal antibody to detect the N-terminal domain (NTD) of the SARS-CoV-2 Spike (S) protein
Category: Primary antibody
Host: Recombinant
Isotype: Human IgG
Species Reactivities: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), SARS-CoV
Immunogen Sequence: Recombinant SARS-CoV-2 Spike protein NTD
Accession #:
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration:
Formulation: In PBS, pH 7.5
Purification:
Application: ELISA
Positive Control:
Application And Usages: ELISA 1:5000 - 1:10,000
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
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