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Product Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Biovision | A2128 | Anti-SHP2 Rabbit Monoclonal Antibody DataSheet
Antibody Target: SHP2
Target Alternative Name: BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2; PTPN11
Tag Line: Affinity purified rabbit monoclonal antibody to detect the expression of SHP2 in human samples
Category: Primary antibody
Host: Rabbit
Isotype: IgG
Species Reactivities: Human
Immunogen Sequence: Synthetic peptide derived from human SHP2
Accession #: Q06124
Gene ID: 5781
Appearance: Colorless liquid
Form: Liquid
Concentration:
Formulation: In PBS with 0.02% sodium azide, 50% glycerol, pH 7.3
Purification: Affinity purified
Application: Western Blotting
Positive Control:
Application And Usages: WB 1:500 - 1:2000
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: TRUE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
