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Product Description
The research-grade biosimilar is a humanized TNF-? monoclonal antibody. The original monoclonal antibody (Certolizumab pegol (CZP)) consists of polyethylene glycol conjugated to the antigen-binding fragment of the humanized monoclonal antibody. The antibody targets and neutralizes soluble and membrane forms of tumor necrosis factor-alpha (TNF-?) and inhibits TNF-? mediated signaling in vitro. Unlike other TNF inhibitors, this antibody does not contain the Fc region. As a result, decreased Fc-mediated effects such as antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) are observed. The original monoclonal antibody received FDA approval to treat moderate to severe rheumatoid arthritis, Crohns disease, ankylosing spondylitis, and psoriatic arthritis.
Biovision | A2142 | Anti-TNF-? (Certolizumab), Humanized Antibody DataSheet
Antibody Target: TNF-?
Target Alternative Name: TNFSF2, TNF-alpha, TNFA, TNF-?, TNF?
Tag Line: A humanized monoclonal antibody that targets and inhibits soluble and membrane forms of TNF-?
Category: Biosimilars
Host: Fab-IgG1-kappa
Isotype: Fab'-G1-kappa
Species Reactivities: Human
Immunogen Sequence: Human TNF-?
Accession #: P01375
Gene ID:
Appearance: Colorless liquid
Form: Liquid
Concentration:
Formulation: In PBS, pH 7.5
Purification:
Application:
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
