Product Description
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Biovision | A1747 | Anti-ALOX5 Antibody DataSheet
Antibody Target: Arachidonate 5-lipoxygenase
Target Alternative Name: 5 LOX, 5-lipoxygenase, Arachidonate 5 lipoxygenase, arachidonic 5-lipoxygenase delta-10-13 isoform, Leukotriene A4 synthase, mgC163204
Tag Line: Polyclonal antibody to detect Anti-ALOX5 Antibody in human, mouse and rat samples.
Category: Signal Transduction
Host: Rabbit
Isotype: IgG
Species Reactivities: Rat, Mouse, Human
Immunogen Sequence: Recombinant protein of human ALOX5
Accession #: P09917
Gene ID: 240
Appearance: Colorless liquid
Form: Liquid
Concentration: 0.7 mg/ml
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Application: Immunohistochemistry (IHC), ELISA
Positive Control:
Application And Usages: IHC 1:50-1:150
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: True
Immunocytochemistry Verified: True
Immunofluorescence Verified: False
Immunoprecipitation Verified: False
FACS Verified: False
ELISA Verified: False
ChIP Verified: False
Dot Blot Verified: False
Flow Cytometry Verified: False