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Product Description
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Biovision | A2116 | Anti-Caspase-3 (Active) Biotinylated Antibody DataSheet
Antibody Target: Caspase 3
Target Alternative Name: CPP32; CPP32B; SCA-1; Active Caspase 3; CASP3; active Caspase-3; Caspase 3; Caspase-3 p12; caspase-3
Tag Line: Rabbit polyclonal antibody to detect biotinylated active Caspase 3 in human samples
Category: Primary antibody
Host: Rabbit
Isotype: IgG
Species Reactivities: Human
Immunogen Sequence: Synthetic peptide mapping to the N-terminus adjacent to the cleavage site of human caspase-3
Accession #: P42574
Gene ID: 836
Appearance: Colorless liquid
Form: Liquid
Concentration: 0.5 mg/ml
Formulation: In PBS, pH 7.2, 30% glycerol, 0.5% BSA, 0.5 mM EDTA and 0.03% proclin
Purification: Antigen Affinity purified
Application: ELISA
Positive Control:
Application And Usages: ELISA 1:500 - 1:2000
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: FALSE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: TRUE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
