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Product Description
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Biovision | A1751 | Anti-Caspase-3 Antibody DataSheet
Antibody Target: Caspase-3
Target Alternative Name: CASP3, Caspase 3, apoptosis-related cysteine protease, CPP32B, Cysteine protease CPP32, SCA-1, SREBP cleavage activity 1
Tag Line: Polyclonal antibody to detect Caspase-3 in human mouse and rat sample.
Category: Neuroscience
Host: Rabbit
Isotype: IgG
Species Reactivities: Rat, Mouse, Human
Immunogen Sequence: Recombinant protein of human CASP3
Accession #: P42574
Gene ID: 836
Appearance: Colorless liquid
Form: Liquid
Concentration: 0.6 mg/ml
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Application: Immunohistochemistry (IHC), Western Blotting, ELISA
Positive Control:
Application And Usages: WB 1:200-1:1000, IHC 1:50-1:200
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: True
Immunocytochemistry Verified: True
Immunofluorescence Verified: False
Immunoprecipitation Verified: False
FACS Verified: False
ELISA Verified: False
ChIP Verified: False
Dot Blot Verified: False
Flow Cytometry Verified: False
