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Product Description
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand-binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Biovision | A2212 | Anti-HER2/ErbB2 Antibody DataSheet
Antibody Target: HER2/ErbB2
Target Alternative Name: HER2, MLN19, NEU, NGL, TKR1, HER-2, HER-2/neu, p185erbB2, CD340, EC 2.7.10.1, MLN 19, C-Erb B2/Neu Protein, CD340 Antigen, HER-2/Neu, Herstatin, EC 2.7.10, ERBB2, MLN19, TKR
Tag Line: Rabbit polyclonal antibody to detect HER2 expression in human, mouse, rat and dog samples
Category: Primary antibody
Host: Rabbit
Isotype: IgG
Species Reactivities: Dog,Rat,Mouse,Human
Immunogen Sequence: KLH-conjugated synthetic peptide targeting a sequence within the center region of human HER2
Accession #: P04626
Gene ID: 2064
Appearance: Colorless liquid
Form: Liquid
Concentration: 1 mg/ml
Formulation: In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide
Purification: Affinity purified
Application: Immunohistochemistry (IHC),Immunofluorescence (IF),Western Blotting
Positive Control:
Application And Usages: WB (1:500 1:1000), IHC (1:100 1:200), IF (1:100 1:500)
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: TRUE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: TRUE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
