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Product Description
Poliovirus receptor-related immunoglobulin domain-containing (PVRIG), also known as CD112 receptor (CD112R), is a 34 kDa transmembrane protein that belongs to the poliovirus receptor-like protein family. It is expressed on T cells and NK cells, but not on monocytes, neutrophils, and B cells. PVRIG binds with high affinity to poliovirus receptor-related 2 (PVRL2/CD112/Nectin-2) and inhibits T-cell mediated immune responses. Expression of PVRIG on T cells is high in multiple cancers such as lung, kidney, breast, ovarian, and endometrial cancers. Blocking of PVRIG alone or in combination with other immune checkpoint proteins such as TIGIT and PD-1 has been demonstrated to increase the production of cytokines and T-cell mediated cytotoxic activity. A novel monoclonal antibody (COM701) has been demonstrated to disrupt the interaction between PVRIG and PVRL2, thus inhibiting tumor growth.
Biovision | A2247 | Anti-PVRIG Antibody DataSheet
Antibody Target: PVRIG
Target Alternative Name: CD112R, C7orf15, PVRIG, MGC2463, CD112 Receptor, Nectin-2 Receptor
Tag Line: Rabbit polyclonal antibody to detect PVRIG expression in human and mouse samples
Category: Primary antibody
Host: Rabbit
Isotype: IgG
Species Reactivities: Mouse,Human
Immunogen Sequence: Recombinant Human Transmembrane protein PVRIG protein (193 - 326 aa)
Accession #: Q6DKI7
Gene ID: 79037
Appearance: Colorless liquid
Form: Liquid
Concentration:
Formulation: In 0.01 M PBS, pH 7.4, 50% Glycerol, 0.03% proclin 300
Purification: Protein G purified
Application: Immunofluorescence (IF),Western Blotting
Positive Control:
Application And Usages: WB 1:1000-1:5000, IF 1:50-1:200
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: TRUE
Immunocytochemistry Verified: FALSE
Immunofluorescence Verified: TRUE
Immunoprecipitation Verified: FALSE
FACS Verified: FALSE
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
