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Product Description
CD163 is a member of the scavenger receptor cysteine-rich (SRCR) superfamily that is exclusively expressed in monocytes and macrophages. It mediates the clearance of hemoglobin/haptoglobin complexes by macrophages, which may protect tissues from free hemoglobin-mediated oxidative damage. CD163 may also mediate innate immunity against bacteria, and plays a role in inflammatory responses. CD163 is upregulated in many inflammatory diseases including liver cirrhosis and rheumatoid arthritis. CD163 expression is associated with Hodgkin lymphoma, and correlates with poor survival outcomes in glioma cases. Recent studies have shown that the depletion of macrophages expressing CD163 can result in a massive recruitment of activated T cells into tumor microenvironments, suggesting a role for CD163 in tumor progression.
Biovision | A2301 | CD163 Rabbit Polyclonal Antibody, for Western DataSheet
Antibody Target: Human CD163
Target Alternative Name: M130; MM130; SCARI1
Tag Line: Plays a role in inflammatory responses
Category: GM-CSF
Host: Rabbit
Isotype: IgG
Species Reactivities: Human Mouse Rat
Immunogen Sequence: Recombinant full length protein of human CD163
Accession #: Q86VB7
Gene ID: 9332
Appearance: Liquid
Form: Rabbit polyclonal
Concentration:
Formulation: In 0.42% potassium phosphate, 0.87% sodium chloride, 30% glycerol; 0.01% sodium azide, pH 7.3
Purification: Affinity purification
Application: Western Blotting
Positive Control:
Application And Usages:
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: TRUE
Immunocytochemistry Verified:
Immunofluorescence Verified: FALSE
Immunoprecipitation Verified: FALSE
FACS Verified:
ELISA Verified: FALSE
ChIP Verified: FALSE
Dot Blot Verified: FALSE
Flow Cytometry Verified: FALSE
