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Product Description
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Biovision | A1965 | Phospho LIMK1/2 (Thr508/505) Antibody DataSheet
Antibody Target: Phospho LIMK1/2 (Thr508/505)
Target Alternative Name: LIMK; LIM domain kinase 1; LIMK-1
Tag Line: Affinity purified rabbit polyclonal antibody to detect phosphorylation of LIMK1/2 at Thr508/505 in human, rat, bovine and chicken samples
Category: Primary antibody
Host: Rabbit
Isotype: IgG
Species Reactivities: Bovine, Rat, Chicken, Human
Immunogen Sequence: KLH-conjugated synthetic peptide targeting a sequence within the C-term region of human LIMK1/2
Accession #: P53667
Gene ID: 3984
Appearance: Colorless liquid
Form: Liquid
Concentration:
Formulation: In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide
Purification: Affinity purified
Application: Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blotting
Positive Control:
Application And Usages: WB 1:500 - 1:1000, IHC 1:100 - 1:200, IF 1:100 - 1:500
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: True
Immunocytochemistry Verified: True
Immunofluorescence Verified: True
Immunoprecipitation Verified: False
FACS Verified: False
ELISA Verified: False
ChIP Verified: False
Dot Blot Verified: False
Flow Cytometry Verified: False
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