Product Description
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Biovision | A1973 | Phospho PAK4 (Ser474) Antibody DataSheet
Antibody Target: Phospho PAK2 (Ser474)
Target Alternative Name: KIAA1142; Serine/threonine-protein kinase PAK 4; p21-activated kinase 4; PAK-4
Tag Line: Affinity purified rabbit polyclonal antibody to detect phosphorylation of PAK4 at Ser474 in human, mouse, rat and bovine samples
Category: Primary antibody
Host: Rabbit
Isotype: IgG
Species Reactivities: Bovine, Rat, Mouse, Human
Immunogen Sequence: KLH-conjugated synthetic peptide targeting a sequence within the C-term region of human PAK4.
Accession #: O96013
Gene ID: 10298
Appearance: Colorless liquid
Form: Liquid
Concentration:
Formulation: In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide
Purification: Affinity purified
Application: Immunofluorescence (IF), Western Blotting
Positive Control:
Application And Usages: WB 1:500 - 1:1000, IF 1:100 - 1:500
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: True
Immunocytochemistry Verified: False
Immunofluorescence Verified: True
Immunoprecipitation Verified: False
FACS Verified: False
ELISA Verified: False
ChIP Verified: False
Dot Blot Verified: False
Flow Cytometry Verified: False