Euro
USD
British Pound
NULL
Product Description
This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis.
Biovision | A1978 | Phospho RET (Tyr1062) Antibody DataSheet
Antibody Target: Phospho RET (Tyr1062)
Target Alternative Name: CDHF12; CDHR16; PTC; RET51; Proto-oncogene tyrosine-protein kinase receptor Ret; Cadherin family member 12; Proto-oncogene c-Ret
Tag Line: Affinity purified rabbit polyclonal antibody to detect phosphorylation of RET at Tyr1062 in human, mouse, rat and monkey samples
Category: Primary antibody
Host: Rabbit
Isotype: IgG
Species Reactivities: Rat, Monkey, Mouse, Human
Immunogen Sequence: KLH-conjugated synthetic peptide targeting a sequence within the C-term region of human RET
Accession #: P07949
Gene ID: 5979
Appearance: Colorless liquid
Form: Liquid
Concentration:
Formulation: In 0.42% Potassium phosphate; 0.87% NaCl; pH 7.3; 30% glycerol; and 0.01% sodium azide
Purification: Affinity purified
Application: Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blotting
Positive Control:
Application And Usages: WB 1:500 - 1:1000, IHC 1:100 - 1:200, IF 1:100 - 1:500
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: True
Immunocytochemistry Verified: True
Immunofluorescence Verified: True
Immunoprecipitation Verified: False
FACS Verified: False
ELISA Verified: False
ChIP Verified: False
Dot Blot Verified: False
Flow Cytometry Verified: False
