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Product Description
Cathepsin K, a member of the papain cysteine proteinase family, is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is produced as an inactive proenzyme (35.4 kDa) that is converted to its mature active form (23.5 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of Procathepsin K to mature Cathepsin K is autocatalytic.
Biovision | 6661 | Procathepsin K Antibody DataSheet
Antibody Target: Procathepsin K
Target Alternative Name: CTSK, CTSO, CTSO3
Tag Line: Polyclonal Antibody to detect Procathepsin K in rat samples
Category: Procathepsin K
Host: Rabbit
Isotype: Rabbit IgG
Species Reactivities: Rat
Immunogen Sequence: Recombinant rat Procathepsin K (Cat # 1029)
Accession #: P00786
Gene ID: 25425
Appearance: Colorless liquid
Form: Liquid
Concentration: 0.5 mg/ml
Formulation: 100 µg (0.5 mg/ml) of antibody in PBS pH 7.2 containing 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol.
Purification: Affinity Purified Antibody
Application: Western blot
Positive Control: Western Blot: Recombinant protein
Application And Usages: Western blot: 1-4 µg/ml.
Country of Animal Origin: USA
Country of Manufacture: USA
Usage: For Research Use Only! Not to be used in humans.
Handling: The antibody solution should be gently mixed before use.
Western Blot Verified: Verified
Immunocytochemistry Verified: Not Verified
Immunofluorescence Verified: Not Verified
Immunoprecipitation Verified: Not Verified
FACS Verified:
ELISA Verified: Not Verified
ChIP Verified: Not Verified
Dot Blot Verified:
Flow Cytometry Verified: Not Verified
