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Product Description
Biovision | K2060 | Aldehyde Dehydrogenase 3A1 Inhibitor Screening Kit (F) DataSheet
Aldehyde Dehydrogenases (ALDHs; EC 1.2.1.3) are oxidizing enzymes that play an important, anti-oxidative role by oxidizing aldehydes generated from the metabolism of amino acids, fatty acids, food, xenobiotic drugs etc. to carboxylic acids. Aldehyde Dehydrogenase 3A1 (ALDH3A1), a member of the ALDH superfamily is highly expressed in various cancers such as hepatoma, lung adenocarcinoma, myeloma, breast cancer etc. It has been shown to play an important role in the survival, metastasis, and chemo-resistance of cancer cells. Thus, the selective inhibition of ALDH3A1 in cancer cells could restore chemosensitivity thereby allowing lower effective dosages and reducing unwanted side effects. BioVision’s ALDH3A1 Inhibitor Screening Kit provides a quick and sensitive way for screening, studying and characterizing the potential inhibitors of ALDH3A1. In this assay, ALDH3A1 oxidizes a specific substrate and generates NADH as one of the intermediate. NADH then couples with the PicoProbe™ to form a stable fluorophore, which is measured at Ex/Em = 535/587 nm. ALDH3A1 Inhibitor Control is included in the kit to compare the efficacy of test inhibitors. The assay is high-throughput adaptable and can be performed within 30-60 min.
Alternate Name : ALDH3A1,ALDH3A1 Inhibitor Screening Kit (F),Aldehyde Dehydrogenase 3A1 Inhibitor Screening Kit,Aldehyde Dehydrogenase 3A1 Inhibitor Screening (F),EC 1.2.1.3,Aldehyde Dehydrogenase 3A1 Inhibitor Screening Kit (F),ALDH3A1 Inhibitor Screening,Aldehyde Dehydrogenase,ALDH3A1 Inhibitor Screening Kit,Aldehyde Dehydrogenase 3A1 Inhibitor Kit (F),Aldehyde Dehydrogenase 3A1,ALDH3A1 Inhibitor Kit (F)
Tag Line : A quick and sensitive way for screening, studying and characterizing the potential inhibitors of ALDH3A1
Summary : Aldehyde Dehydrogenases (ALDHs; EC 1.2.1.3) are oxidizing enzymes that play an important, anti-oxidative role by oxidizing aldehydes generated from the metabolism of amino acids, fatty acids, food, xenobiotic drugs etc. to carboxylic acids. Aldehyde Dehydrogenase 3A1 (ALDH3A1), a member of the ALDH superfamily is highly expressed in various cancers such as hepatoma, lung adenocarcinoma, myeloma, breast cancer etc. It has been shown to play an important role in the survival, metastasis, and chemo-resistance of cancer cells. Thus, the selective inhibition of ALDH3A1 in cancer cells could restore chemosensitivity thereby allowing lower effective dosages and reducing unwanted side effects. BioVision’s ALDH3A1 Inhibitor Screening Kit provides a quick and sensitive way for screening, studying and characterizing the potential inhibitors of ALDH3A1. In this assay, ALDH3A1 oxidizes a specific substrate and generates NADH as one of the intermediate. NADH then couples with the PicoProbe™ to form a stable fluorophore, which is measured at Ex/Em = 535/587 nm. ALDH3A1 Inhibitor Control is included in the kit to compare the efficacy of test inhibitors. The assay is high-throughput adaptable and can be performed within 30-60 min.
Detection Method :
Sample Type :
Species Reactivity : Human
Applications : Screening and characterizing potential ALDH3A1 inhibitors.
Features and Benefits : ALDH3A1 Inhibitor Screening Kit provides a quick and sensitive way for screening, studying and characterizing the potential inhibitors of ALDH3A1.,The assay is high-throughput adaptable and can be performed within 30-60 min.
