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Product Description
Biovision | K2069 | Furin Inhibitor Screening Kit (Fluorometric) DataSheet
Furin is a serine protease that belongs to the subtilisin-like Proprotein Convertases (PCs) family. PCs family members are calcium-dependent serine endoproteases that process latent, immature precursor proteins into their biologically active, functional form. Furin is predominantly localized in the Golgi apparatus, where it functions to cleave other proteins into their mature, active forms. However, it cycles between Golgi, cell surface, and the endosomes. Furin plays an important role in numerous processes including cell survival, migration, maintenance of homeostasis, embryogenesis, and in diseases. In addition to processing precursor proteins, Furin is utilized by numerous viral and bacterial pathogens for enhancing their virulence and spread. For example, the envelope protein of viruses such as HIV, influenza, several filoviruses including Ebola and Marburg virus, and the spike protein of SARS-CoV-2 must be cleaved by furin or furin-like proteases to become fully functional. Because of the role of Furin in many cellular processes and diseases, it is emerging as a potential therapeutic target for infectious and non-infectious diseases. BioVision’s Furin Inhibitor Screening Kit provides a quick, easy and sensitive assay for screening, studying and characterizing potential inhibitors of Furin. In this assay, Furin cleaves a fluorescent peptidyl substrate and generates a fluorescence signal, which is detected at Ex/Em = 360/460 nm. A potent, specific Furin inhibitor is also included in the kit.
Alternate Name : Furin Inhibitor Screening Kit,Furin Inhibitor Screening Assay Kit,Furin Inhibitor Screening (Fluorometric),Furin Inhibitor Screening Kit Assay (Fluorometric)
Tag Line : For screening, studying and characterizing potential inhibitors of Furin
Summary : BioVision’s Furin Inhibitor Screening Kit provides a quick, easy and sensitive assay for screening, studying and characterizing potential inhibitors of Furin. In this assay, Furin cleaves a fluorescent peptidyl substrate and generates a fluorescence signal, which is detected at Ex/Em = 360/460 nm. A potent, specific Furin inhibitor is also included in the kit.
Detection Method : Fluorescence (Ex/Em = 360/460 nm)
Sample Type : Potential Furin inhibitors
Species Reactivity : Human
Applications : Screening or characterizing Furin inhibitors.
Features and Benefits : A potent, specific Furin inhibitor is also included in the kit.,A quick, easy and sensitive assay for screening, studying and characterizing potential inhibitors of Furin.
