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Product Description
MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote the survival, growth and function of dopamine-specific neurons. MANF can prevent 6-OHDA-induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson's disease. Expression of MANF has also been shown to be induced during ER stress, suggesting that it may play a role in protein quality control during ER stress.
Biovision | P1706 | Active MANF, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: arginine-rich, mutated in early stage tumors; Protein ARMET Mesencephalic Astrocyte-derived Neurotrophic Factor, ARMET, Arginine-rich protein (ARP)
Alternates names:
Taglines: A secreted neurotrophic factor that is mutated in a variety of tumors
NCBI Gene ID #: 7873
NCBI Gene Symbol:
Gene Source: Human
Accession #: P55145
Recombinant: True
Source: E.coli
Purity by SDS-PAGE: ≥ 98% by SDS-PAGE gel and HPLC analyses
Assay:
Purity:
Assay #2:
Endotoxin Level:
Activity (Specifications/test method):
Biological activity: Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 ug/ml.
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: 18.1 kDa
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized protein powder
Reconstitution Instructions: Reconstitute to desired concentration using sterile water
Amino acid sequence: LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGKENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKIL DDWGETCKGC AEKSDYIRKI NELMPKYAPK AASARTDL
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
