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Product Description
Protein arginine deiminases (PADs) are a family of guanidine-modifying enzymes that catalyze the post-translational modification of target proteins by converting arginine to citrulline. Excessive citrullination of proteins may result in disease states. PAD4 (also known as PADI5) is expressed in neutrophils and in a variety of tissues. PAD4 is known to citrullinate histones, which initiates chromatin decondensation in neutrophils and the subsequent release of neutrophil extracellular traps (NETs), which leads to a lytic form of cell death known as NETosis. The presence of serum PAD4 autoantibodies has been associated with rheumatoid arthritis.
Biovision | P1720 | Active PAD4, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: Peptidyl Arginine Deiminase 4; PDI5; Peptidyl Arginine Deiminase, Type IV; Peptidyl Arginine Deiminase, Type V; Protein-Arginine Deiminase Type IV; Protein-Arginine Deiminase Type-4; EC 3.5.3.15; HL-60 PAD; PADI5; PDI4; PAD; Peptidylarginine Deiminase IV; PADI-H Protein; PADI4
Alternates names:
Taglines: Protein arginine deiminase associated with rheumatoid arthritis
NCBI Gene ID #: 23569
NCBI Gene Symbol:
Gene Source: Human
Accession #: Q9UM07
Recombinant: True
Source: E.coli
Purity by SDS-PAGE: ≥ 85% by SDS-PAGE
Assay:
Purity:
Assay #2:
Endotoxin Level:
Activity (Specifications/test method): Activity output measured by the production of ammonium ions when enzyme acts on N-benzoyl-L-arginine ethyl ester (BAEE) substrate
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: 75.8 kDa
Concentration:
Appearance: Liquid protein
Physical form description: Liquid
Reconstitution Instructions:
Amino acid sequence: Full length human PAD4 protein (amino acids 2 to 663) with N-terminal His tag
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
