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Product Description
The transmembrane serine protease 2 (TMPRSS2) plays an important role in the infection mechanism of human coronaviruses such as SARS-CoV-2. Cell entry of SARS-CoV-2 depends on the binding of the viral spike (S) glycoprotein to the ACE2 receptor and S protein priming by TMPRSS2. TMPRSS2 is also shown to be upregulated by androgen in prostate cancer cells, and downregulated in androgen-independent prostate cancer.
Biovision | P1735 | Active Transmembrane Serine Protease 2 (TMPRSS2), Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: Transmembrane Serine Protease 2; PRSS10; Serine Protease 10; Epitheliasin
Alternates names: Transmembrane Serine Protease 2; PRSS10; Serine Protease 10; Epitheliasin
Taglines: A biomarker in prostate cancer and a point of cell entry for SARS-CoV-2
NCBI Gene ID #: 7113
NCBI Gene Symbol:
Gene Source: Human
Accession #: O15393
Recombinant: True
Source: Yeast
Purity by SDS-PAGE: > 85% by SDS-PAGE
Assay:
Purity:
Assay #2:
Endotoxin Level:
Activity (Specifications/test method): Recombinant Human TMPRSS2 enzyme activity is measured by its ability to cleave fluorogenic peptide substrate (Boc-Gln-Ala-Arg-AMC), Km is 21.93 uM.
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: 44.8 kDa (calculated)
Concentration:
Appearance: Liquid protein
Physical form description: Liquid
Reconstitution Instructions:
Amino acid sequence: Partial sequence of TMPRSS2 (amino acids 106 to 492) with N-terminal 6xHis Tag
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
