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Product Description
BID is a pro-apoptotic Bcl-2 protein containing only the BH3 domain. In response to apoptotic signaling, BID interacts with another Bcl-2 family protein, Bax, leading to the insertion of Bax into the outer mitochondrial membrane. Bax is believed to induce the opening of the mitochondrial voltage-dependent anion channel. This results in the release of cytochrome c and other pro-apoptotic factors from the mitochondria leading to activation of caspases. Recombinant BID protein was expressed in E. coli and purified by using conventional chromatography techniques.
Biovision | P1571 | BID, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: BH3-interacting domain death agonist, p22 BID, p11 BID
Alternates names: BH3-interacting domain death agonist, p22 BID, p11 BID
Taglines: Pro-apoptotic Bcl-2 protein
NCBI Gene ID #: 637
NCBI Gene Symbol: BID
Gene Source: Human
Accession #: P55957
Recombinant: TRUE
Source: E. coli
Purity by SDS-PAGE: >95%
Assay: SDS - PAGE
Purity:
Assay #2:
Endotoxin Level:
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: 21.9 kDa
Concentration:
Appearance: Sterile Filtered colorless solution
Physical form description: In 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol
Reconstitution Instructions:
Amino acid sequence: aa 1-195
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
