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Product Description
Biovision | Cathepsin L (Active), Human Liver | 7539
Description: Cathepsin L is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Substrates for Cathepsin L include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. Cathepsin L has been implicated in myofibril necrosis in some muscle diseases, and in the renal tubular response to proteinuira. Levels of Cathepsin L is a strong predictor of relapse and survival following primary breast tumor treatment. Recently, Cathepsin L has been shown to cleave the S1 subunit of the SARS-CoV-2 spike protein, which allows viral intry into the cell.
Biomolecule/Target:
Synonyms: Cathepsin L1; Major Excreted Protein; CTSL; CTSL1
Alternates names:
Taglines: Plays a major role in intracellular protein catabolism
NCBI Gene ID #: 1514
NCBI Gene Symbol: Human
Accession #: P07711
Recombinant: False
Source: Human liver
Purity by SDS-PAGE:
Assay:
Purity:
Assay #2:
Endotoxin Level:
Activity (Specifications/test method): Greater than 1 unit per mg of protein, where one unit is defined as the amount of enzyme needed to hydrolyze one micromole of Z-Phe-Arg-AFC per minute at 25 C using 400 mM sodium acetate, pH 5.5. with 4 mM EDTA and 8 mM DTT as the activation buffer in the presence of Brij detergent.
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: 25 to 29 kDa
Concentration:
Appearance: Sterile Filtered colorless solution
Physical form description: Frozen
Reconstitution Instructions:
Amino acid sequence:
Handling: Centrifuge the vial prior to opening.
Usage:
