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Product Description
Human B7 homolog 3 (B7-H3) is a member of the B7 family of immune proteins that provide signals for the regulation of immune responses. Other family members include B7-1, B7-2, B7-H1/PD-L1, B7-H2, and PD-L2. B7 family proteins are type I transmembrane immunoglobulin (Ig) superfamily members that contain extracellular Ig V‑like and Ig C‑like domains with a short cytoplasmic tail. Termed 4IgB7-H3 or B7-H3b, this molecule has two additional Ig-like domains (one V‑type and one C‑type) and shows a ubiquituous expression pattern.
Biovision | P1388 | Human CellExp™ B7-H3 / CD276, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: 4Ig-B7-H3, B7-H3, CD276, PSEC0249, UNQ309/PRO352, B7 homolog 3
Alternates names: 4Ig-B7-H3, B7-H3, CD276, PSEC0249, UNQ309/PRO352, B7 homolog 3
Taglines: Regulate the T-cell-mediated immune response and a protective role in tumor cells by inhibiting natural-killer mediated cell lysis. Marker for detection of neuroblastoma cells
NCBI Gene ID #: 80381
NCBI Gene Symbol: CD276
Gene Source: Human
Accession #: Q5ZPR3
Recombinant: FALSE
Source: HEK 293 cells
Purity by SDS-PAGE: >95% as determined by SDS-PAGE.
Assay:
Purity:
Assay #2:
Endotoxin Level: Less than 1.0 EU per ug by the LAL method.
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 48.5 kDa. The protein migrates as 65-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 ug/ml. Do not vortex. It is recommended to store at -20°C.
Amino acid sequence: AA Gly 27 - Thr 461
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
