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Product Description
The Killer Cell Lectin Like Receptor C1 (KLRC1, also known as CD159a) is a member of the NKG2 family, a group of transmembrane proteins preferentially expressed in natural killer (NK) cells. KLRC1 forms a complex with KLRD1 (CD94), and is implicated in the reccognition of the MHC class I HLA-E molecules in NK cells. KLRC1 enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self, as well as monitoring the activation and effector functions of NK cells. In viral infections and some tumor microenvironments, KLRC1 is a key target to downregulate NK cell cytotoxicity and allow tumor progression and viral escape from immune surveillance.
Biovision | P1730 | Human CellExp™ CD159a / KLRC1 (Active), Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: Killer Cell Lectin Like Receptor C1; NKG2-A/NKG2-B Type II Integral Membrane Protein; NKG2-A; NKG2-B; NKG2
Alternates names: Killer Cell Lectin Like Receptor C1; NKG2-A/NKG2-B Type II Integral Membrane Protein; NKG2-A; NKG2-B; NKG2
Taglines: An immune inhibitory receptor involved in self-nonself discrimination
NCBI Gene ID #: 3821
NCBI Gene Symbol:
Gene Source: Human
Accession #: P26715
Recombinant: True
Source: Human Cells
Purity by SDS-PAGE: > 95% by SDS-PAGE
Assay:
Purity:
Assay #2:
Endotoxin Level: < 1.0 EU per ug as determined by the LAL method
Activity (Specifications/test method): Immobilized Human KLRC1-His at 10 ug/ml (100 ul/well) can bind Biotinylated Human CD94-His. The ED50 of Human KLRC1-His is 18 ug/mL.
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: 16.5 kDa calculated; 25-40 kDa observed
Concentration:
Appearance: Lyophilized protein
Physical form description:
Reconstitution Instructions:
Amino acid sequence: Arg 100 to Leu 233 with N-terminal 8xHis Tag
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
