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Product Description
Neuropilin-1 (NRP1) is also known as Vascular endothelial cell growth factor 165 receptor (VEGF165R), CD antigen CD304, which belongs to the neuropilin family. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells.
Biovision | P1409 | Human CellExp™ CD304 / NRP1 / Neurophilin-1, Fc Tag, mouse recombinant DataSheet
Biomolecule/Target :
Synonyms: NRP1, Neuropilin-1, NRP, VEGF165R, CD304
Alternates names: NRP1, Neuropilin-1, NRP, VEGF165R, CD304
Taglines: A receptor involved in the development of the cardiovascular system
NCBI Gene ID #: 18186
NCBI Gene Symbol: Nrp1
Gene Source: Mouse
Accession #: P97333-1
Recombinant: True
Source: HEK 293 cells
Purity by SDS-PAGE: >90%
Assay: SDS-PAGE
Purity:
Assay #2:
Endotoxin Level: Less than 0.1 EU per ug by the LAL method.
Activity (Specifications/test method): Immobilized Human VEGF165, Tag Free at 2 ug/mL (100 uL/well) can bind Mouse NRP1, Mouse IgG2a Fc Tag with a linear range of 0.5-4 ng/mL
Biological activity:
Results:
Binding Capacity: Immobilized Human VEGF165, Tag Free at 2 ug/mL (100 uL/well) can bind Mouse NRP1, Mouse IgG2a Fc Tag with a linear range of 0.5-4 ng/mL
Unit Definition:
Molecular Weight: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 120.5 kDa. The protein migrates as 125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Amino acid sequence: AA Phe 22 - Pro 856
Handling: Centrifuge the vial prior to opening.
Usage:
