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Product Description
Growth Differentiation Factor 15 (GDF15), also known as Macrophage inhibitory cytokine 1 (MIC-1), is a protein belonging to the TGF-beta superfamily. Like other proteins in the superfamily, it is expressed as a large precursor protein and cleaved at an (RxxR) furin-like cleavage site to release the mature protein. GDF15 is highly expressed in mammalian tissue with higher levels in the placenta and brain and lower levels in the kidney, prostate, colon. Its expression is tightly regulated and often induced in response to cellular stress. Additionally, GDF15 has been shown to have various functions, including inhibition of Tumor Necrosis Factor alpha (TNF-alpha) production from lipopolysaccharide-stimulated macrophages and the induction of cartilage formation. Some studies have also implicated GDF15 serum levels to have a strong association with many diseases like cancer, cardiovascular diseases, and obesity, and could potentially serve as a reliable biomarker for disease progression.
Biovision | P1546 | Human CellExp™ GDF-15, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: Growth Differentiation Factor 15, MIC-1, Macrophage Inhibitory Cytokine 1, NSAID-activated gene 1 protein, NAG-1, NSAID-regulated gene 1 protein, NRG-1, Placental TGF-beta, Placental bone morphogenetic protein, Prostate differentiation factor
Alternates names: Growth Differentiation Factor 15, MIC-1, Macrophage Inhibitory Cytokine 1, NSAID-activated gene 1 protein, NAG-1, NSAID-regulated gene 1 protein, NRG-1, Placental TGF-beta, Placental bone morphogenetic protein, Prostate differentiation factor
Taglines: A protein with functions in regulating inflammatory and apoptotic pathways
NCBI Gene ID #: 9518
NCBI Gene Symbol: GDF-15
Gene Source: Human
Accession #: Q99988
Recombinant: TRUE
Source: HEK 293 cells
Purity by SDS-PAGE: >95%
Assay: SDS - PAGE
Purity:
Assay #2:
Endotoxin Level:
Activity (Specifications/test method):
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Unit Definition:
Molecular Weight: 12 kDa Monomer (His-tag at the C-terminus)
Concentration:
Appearance: Lyophilized protein
Physical form description: Lyophilized
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile 4mM acetic acid. Do not vortex.
Amino acid sequence: Ala 195 - Ile 308
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
