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Product Description
Interleukin-1 (IL-1) is produced by activated macrophages and stimulates thymocyte proliferation by inducing IL-2 release. IL-1 also induces B-cell maturation and proliferation, and modulates fibroblast growth factor activity. IL-1 proteins have been identified as endogenous pyrogens, and are involved in the inflammatory response.
Biovision | P1717 | Human CellExp™ IL-1α, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: Interleukin-1 alpha; Hematopoietin-1; IL1; IL-1A; IL1F1; IL1-ALPHA; IL-1 alpha
Alternates names:
Taglines: Critical mediator of inflammatory response
NCBI Gene ID #: 3552
NCBI Gene Symbol:
Gene Source: Human
Accession #: P01583
Recombinant: True
Source: HEK 293 cells
Purity by SDS-PAGE: ≥ 95% by SDS-PAGE
Assay:
Purity:
Assay #2:
Endotoxin Level: < 1 EU per 1 ug of protein as determined by LAL method
Activity (Specifications/test method):
Biological activity: Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells (ED50 typically 0.2-1 ng/mL) and by its ability to induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells (ED50 typically 0.07-0.35 ug/mL)
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: 18 kDa calculated; 22 kDa observed
Concentration:
Appearance: Liquid protein
Physical form description: Lyophilized powder
Reconstitution Instructions:
Amino acid sequence: Ser 113 to Ala 271 of human IL-1α
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
