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Product Description
Interleukin-31 receptor subunit alpha is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha, IL-31RA, GLM-R, Gp130-like receptor, CRL3, GPL. Oncostatin M receptor (OSMR) and IL31RA form the heterodimeric receptor through which IL31 signals. IL31RA is a strong activator of STAT3 and STAT5, whereas STAT1 is only marginally tyrosine-phosphorylated. dditionally, demonstrate Jak1 binding to GPL and its activation in heteromeric complexes with the OSMRbeta but also in a homomeric receptor complex.
Biovision | P1413 | Human CellExp™ IL-31, Fc Tag, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: IL-31 RA, IL-31RA, hGLM-R, CRL3, GPL, ZcytoR17, GLM-R, IL-31R-alpha, Gp130-like receptor
Alternates names: IL-31 RA, IL-31RA, hGLM-R, CRL3, GPL, ZcytoR17, GLM-R, IL-31R-alpha, Gp130-like receptor
Taglines: Function in skin immunity
NCBI Gene ID #: 133396
NCBI Gene Symbol: IL31RA
Gene Source: Human
Accession #: Q8NI17-1
Recombinant: True
Source: HEK 293 cells
Purity by SDS-PAGE: >95%
Assay: SDS-PAGE
Purity:
Assay #2:
Endotoxin Level: Less than 0.1 EU per ug by the LAL method.
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 83.5 kDa. The protein migrates as 105-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Amino acid sequence: AA Ala 20 - Glu 519
Handling: Centrifuge the vial prior to opening.
Usage:
