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Product Description
Myelin-associated glycoprotein (MAG), a nervous system cell adhesion molecule, is an I-type lectin that binds to sialylated glycoconjugates, including gangliosides bearing characteristic structural determinants. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. In dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides.
Biovision | P1480 | Human CellExp™ MAG / Siglec-4a, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: MAG, Siglec-4a, GMA, S-MAG
Alternates names: MAG, Siglec-4a, GMA, S-MAG
Taglines: Adhesion molecule that mediates interactions between myelinating cells and neurons
NCBI Gene ID #: 4099
NCBI Gene Symbol: MAG
Gene Source: Human
Accession #: P20916-1
Recombinant: True
Source: HEK 293 cells
Purity by SDS-PAGE: >95%
Assay:
Purity:
Assay #2:
Endotoxin Level: Less than 1.0 EU per ug by the LAL method.
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 56.6 kDa. The protein migrates as 65-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Amino acid sequence: Gly 20 - Pro 516
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
