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Product Description
PDGF-CC is a member of the platelet-derived growth factor (PDGF) family, which was originally identified as a serum growth factor for fibroblasts, smooth muscle cells and glia cells. The PDGF family consists of proteins derived from four genes (PDGF-A, -B, -C, and -D) that form four disulfide-linked homodimers (PDGF-AA, -BB, -CC, and -DD) and one heterodimer (PDGF-AB). These proteins regulate diverse cellular functions by binding to and inducing the homo- or hetero-dimerization of two receptor tyrosine kinases (PDGF R alpha and R beta). PDGF-CC is expressed in multiple embryonic and adult cell types and tissues. PDGF-CC is involved in pathogenesis of neurologic diseases, cancer and fibrosis. The PDGF-CC ligand has also been shown to be involved in tumor growth by paracrine signaling through PDGFRα in malignant melanoma and cervical carcinoma.
Biovision | P1526 | Human CellExp™ PDGF-CC, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: Platelet-derived growth factor C, PDGFCC; PDGF-CC, Fallotein, Spinal cord-derived growth factor, SCDGF, VEGF-E
Alternates names: Platelet-derived growth factor C, PDGFCC; PDGF-CC, Fallotein, Spinal cord-derived growth factor, SCDGF, VEGF-E
Taglines: Potent mitogen for a variety of cell types
NCBI Gene ID #: 56034
NCBI Gene Symbol: PDGFC
Gene Source: Human
Accession #: Q9NRA1
Recombinant: TRUE
Source: HEK 293 cells
Purity by SDS-PAGE: >95%
Assay: SDS - PAGE
Purity:
Assay #2:
Endotoxin Level:
Activity (Specifications/test method):
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: 16 kDa (6×His tag at the C-terminus)
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Amino acid sequence: aa Val 235 – Gly 345
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
