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Product Description
Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) is also known as Decoy Receptor 3 (DcR3), Decoy receptor for Fas ligand and M68, which belongs to the tumor necrosis factor receptor superfamily. TNFRSF6 is a soluble protein which contains four TNFR-Cys repeats. Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain. TNFRSF6B acts as a decoy receptor that competes with death receptors for ligand binding. The protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A.
Biovision | P1492 | Human CellExp™ TNFRSF6B, Fc Tag, Human Recombinant DataSheet
Biomolecule/Target :
Synonyms: TNFRSF6B, DCR3, TR6, M68
Alternates names: TNFRSF6B, DCR3, TR6, M68
Taglines: Acts as a decoy receptor that competes with death receptors for ligand binding
NCBI Gene ID #: 8771
NCBI Gene Symbol: CFD
Gene Source: Human
Accession #: O95407-1
Recombinant: True
Source: HEK 293 cells
Purity by SDS-PAGE: >95%
Assay:
Purity:
Assay #2:
Endotoxin Level: Less than 1.0 EU per ug by the LAL method.
Activity (Specifications/test method): Immobilized Human LIGHT, Mouse IgG2a Fc Tag, low endotoxin at 5 ug/mL (100 uL/well) can bind Human DcR3, Fc Tag with a linear range of 5-20 ng/mL
Biological activity:
Results:
Binding Capacity:
Unit Definition:
Molecular Weight: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 56.2 kDa. The protein migrates as 65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Concentration:
Appearance: Lyophilized powder
Physical form description: Lyophilized
Reconstitution Instructions: Reconstitute in sterile deionized water to the desired protein concentration.
Amino acid sequence: AA Val 30 - His 300
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans
